PasqualeArpaia,Umberto Cesaro,Nicola Moccaldi,Isabella Sannino
Non-Invasive Monitoring of Transdermal Drug Delivery
Non-Invasive Monitoring of Transdermal Drug Delivery
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Excellent- More about Non-Invasive Monitoring of Transdermal Drug Delivery
This book presents an innovative technology based on injection of a weak current to trace the quantity of a drug carried immediately after administration. It covers the method of transdermal drug delivery, screening measurement campaign, prototyping, validation, and characterization of an instrument, experimental campaigns, and a behavioral model. It is intended for biomedical engineers, biomedical engineering students, operators, biotechnologists, and technicians of transdermal vehiculation.
Format: Hardback
Length: 174 pages
Publication date: 24 March 2022
Publisher: Taylor & Francis Ltd
This groundbreaking book presents an innovative technology based on the injection of a very weak current to trace the quantity of a drug carried immediately after the administration. It delves into the realm of transdermal drug delivery, providing the reader with a comprehensive understanding of the technology from its conception to its preliminary clinical applications.
In the first chapter, the method of transdermal drug delivery and the use of impedance spectroscopy in the dermatological field are explored. The second chapter details a comprehensive screening measurement campaign aimed at proving the feasibility of the assessment method and identifying the bandwidth of interest. Chapter three showcases the prototyping, validation, and characterization of an instrument designed to measure the amount of drug delivered (DUSM: Drug Under Skin Meter).
Chapter four presents three experimental campaigns, each based on the electrical analysis of the biological tissue behavior due to drug delivery. These campaigns involve laboratory emulation on eggplants, ex-vivo tests on pig ears, and in-vivo tests on human volunteers.
In the fifth chapter, a behavioral model is proposed, based on Finite Elements and Partial Differential Equation, to assess the drug released under the skin during transdermal delivering. The last chapter focuses on a campaign to prove the suitability of this technology for insulin therapy applications.
This book is meticulously crafted for biomedical engineers, biomedical engineering students, operators working in the field of biomedical instrumentation, biotechnologists, and technicians involved in transdermal vehiculation. It serves as a valuable resource for those seeking to advance their knowledge and expertise in this rapidly evolving field.
Dimension: 234 x 156 (mm)
ISBN-13: 9780367765989
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