Novel Approaches to Colorectal Cancer

Novel Approaches to Colorectal Cancer, Volume 151 in the Advances in Cancer Research series, contains 11 reviews on state-of-the-art research on colorectal cancer, including molecular biomarkers, diet, lifestyle, microbiome, early-age onset, mutational signature analysis, early detection, immunotherapy, organoid technology, epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process.

Format: Hardback
Length: 484 pages
Publication date: 18 June 2021
Publisher: Elsevier Science Publishing Co Inc

Novel Approaches to Colorectal Cancer,Volume 151 in the Advances in Cancer Research series, is a comprehensive compilation of 11 reviews that delve into the latest advancements in understanding, diagnosing, preventing, and treating colorectal cancer. This esteemed volume features contributions from renowned experts in the field, encompassing diverse topics such as molecular biomarkers in diagnosis and therapy, the intricate interplay between diet, lifestyle, and the microbiome, the prevalence of early-age onset disease, mutational signature analysis, challenges in early detection, immunotherapy, organoid technology, the role of epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process.

Within these chapters, readers are presented with novel insights and concepts that shed light on various facets of colorectal cancer, offering promising avenues for managing this significant contributor to cancer incidence and mortality. The authors of these reviews have made substantial contributions to the field, providing a valuable resource for researchers, clinicians, and healthcare professionals alike.

The interplay between diet, lifestyle, and the microbiome plays a crucial role in the development and progression of colorectal cancer. The authors explore the impact of dietary habits, such as the consumption of fruits, vegetables, whole grains, and lean proteins, on cancer risk reduction and the potential benefits of a Mediterranean-style diet. They also discuss the role of the gut microbiome in shaping immune responses and the development of colorectal cancer.

Early-age onset disease is a significant concern in the field of colorectal cancer, with a higher prevalence observed in younger individuals. The authors examine the genetic and environmental factors that contribute to the development of early-age onset disease and explore novel diagnostic and therapeutic strategies for this population.

Mutational signature analysis is a powerful tool for identifying specific genetic mutations that are associated with colorectal cancer development. The authors discuss the latest advancements in this field, including the use of next-generation sequencing technologies and bioinformatics approaches, and their potential applications in personalized cancer treatment.

Challenges in early detection of colorectal cancer remain a significant concern, as the disease often exhibits no symptoms in its early stages. The authors explore innovative screening techniques, such as fecal occult blood testing, colonoscopy, and virtual colonoscopy, and their effectiveness in reducing cancer mortality.

Immunotherapy has emerged as a promising treatment option for colorectal cancer, particularly in advanced stages. The authors discuss the mechanisms of immune response in colorectal cancer and the development of immunotherapeutic agents, such as checkpoint inhibitors and adoptive cell therapy, that have shown promising results in clinical trials.

Organoid technology is a novel approach for studying colorectal cancer in vitro and has the potential to revolutionize cancer research and treatment. The authors explore the use of organoids in modeling cancer development, drug testing, and personalized medicine.

Epigenetic alterations play a significant role in the development and progression of colorectal cancer. The authors discuss the mechanisms of epigenetic regulation and the potential applications of epigenetic therapies in cancer treatment.

Disparities in minority populations are a significant concern in the field of colorectal cancer, with a higher incidence and mortality rates observed in certain ethnic groups. The authors explore the social, economic, and healthcare factors that contribute to these disparities and propose strategies for addressing them.

Field carcinogenesis is a process by which environmental factors, such as exposure to pollutants or chemicals, contribute to the development of colorectal cancer. The authors discuss the latest research on the role of field carcinogenesis in colorectal cancer development and the potential for prevention.

Cancer as an evolutionary process is a novel perspective that explores the relationship between cancer and other biological processes. The authors discuss the evolution of cancer and its potential implications for cancer treatment and prevention.

In conclusion, Novel Approaches to Colorectal Cancer,Volume 151 in the Advances in Cancer Research series, provides a comprehensive and up-to-date overview of the latest research and advancements in understanding, diagnosing, preventing, and treating colorectal cancer. This volume is a valuable resource for researchers, clinicians, and healthcare professionals seeking to stay informed about the latest developments in this field. By exploring diverse topics such as molecular biomarkers, diet-lifestyle interactions, early-age onset disease, mutational signature analysis, immunotherapy, organoid technology, epigenetic alterations, disparities in minority populations, field carcinogenesis, and cancer as an evolutionary process, this book offers novel insights and concepts that have the potential to transform the management and treatment of colorectal cancer.

Weight: 910g
Dimension: 229 x 152 (mm)
ISBN-13: 9780128240786