Nucleic Acid Biology and its Application in Human Diseases

This book explores the structure-function relationship of nucleic acids, their role in disease pathophysiology, and their potential as therapeutic targets. It discusses recent advancements in nucleic acid-based therapy, diagnostics, nanotechnology, and materials. It also examines the role of DNA methylation, chromatin components, and microRNAs in cancer progression. The book highlights the applications of nucleic acids as vaccines and gene-editing tools and discusses clinical trials using genome editing platforms. It also addresses challenges associated with nucleic acid-mediated therapy.

Format: Hardback
Length: 416 pages
Publication date: 29 April 2023
Publisher: Springer Verlag, Singapore

This comprehensive book delves into the intricate structure-function relationship of nucleic acids, exploring their profound role in the pathophysiology of various human diseases and their potential as therapeutic targets. The chapters delve into the intricate details of nucleic acids' involvement in inflammatory diseases, neurodegenerative disorders, and cancer, shedding light on their underlying mechanisms and implications for disease management. Furthermore, the book showcases recent advancements in nucleic acid-based therapy, highlighting their effectiveness in treating a wide range of conditions. It also discusses the application of nucleic acids in diagnostics, enabling precise and personalized disease detection and monitoring. Additionally, the book explores the development of nano-carriers, logic gates, and sensors based on nucleic acids, expanding their potential applications in various fields.

The book further examines the unique and multifunctional capabilities of nucleic acids (RNA and DNA) as platforms for diverse applications, including therapeutics, diagnostics, nanodevices, and materials. It delves into the role of DNA methylation, histone modifiers, chromatin remodelers, microRNAs, and other components of chromatin in the progression of cancer, providing valuable insights into cancer diagnosis and treatment. Moreover, the book discusses the applications of nucleic acids as vaccines and gene-editing tools, offering promising solutions for disease prevention and treatment.

In conclusion, this book serves as a valuable resource for researchers, healthcare professionals, and students interested in understanding the role of nucleic acids in human diseases and their potential for therapeutic intervention. It provides a comprehensive overview of nucleic acids' structure, function, and applications, covering a wide range of topics and highlighting recent advancements in this field.

Weight: 805g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811985195
Edition number: 1st ed. 2023