Ophthalmic Product Development: From Bench to Bedside

This textbook covers the anatomy and physiology of the eye, as well as drug development for ophthalmic use, including topical and intraocular formulations, small molecules and biologics, conventional formulations, novel formulations, devices, and specialty products. It also discusses critical elements such as pharmacokinetics, formulation technologies, and disease conditions.

Format: Hardback
Length: 650 pages
Publication date: 08 February 2022
Publisher: Springer Nature Switzerland AG

This extensive textbook delves into the intricate realm of drug development specifically tailored for ophthalmic applications. It begins by offering a comprehensive overview of the anatomy and physiology of the eye, serving as a foundational framework for understanding the unique challenges and considerations in ocular drug product development. The book then proceeds to critically evaluate the principles that govern this field, encompassing a wide range of topics such as topical and intraocular formulations, small molecules and biologics (including protein and gene therapies), conventional formulations (including solutions, suspensions, and emulsions), novel formulations (including nanoparticles, microparticles, and hydrogels), devices, and specialty products.

A central focus of the text is the exploration of critical elements such as pharmacokinetics, the influence of formulation technologies and ingredients, and the impact of disease conditions on product development. The authors delve into the intricacies of drug absorption, distribution, metabolism, and excretion within the eye, taking into account factors such as ocular tissue properties, blood-ocular barrier permeability, and potential drug interactions.

Furthermore, the book addresses the development of products intended for both the front and back of the eye, recognizing the distinct anatomical and physiological characteristics of theseocular regions. It explores emerging trends and advancements in ophthalmic drug delivery systems, including innovative technologies such as nanotechnology, gene therapy, and stem cell-based therapies. The authors also discuss the regulatory considerations and approval processes involved in bringing ophthalmic drugs to market, emphasizing the importance of rigorous clinical trials and post-marketing surveillance.

Throughout the textbook, real-world case studies and examples are provided to illustrate the practical applications and challenges of ophthalmic drug development. These case studies showcase successful products, as well as challenges encountered during the development process, providing valuable insights for researchers, pharmaceutical professionals, and students alike.

In conclusion, this comprehensive textbook serves as a valuable resource for anyone interested in drug development for ophthalmic applications. It provides a thorough and up-to-date understanding of the unique aspects of ocular drug product development, covering a wide range of topics and critical elements. By presenting a balanced perspective and real-world examples, the book equips readers with the knowledge and skills necessary to contribute to the advancement of ophthalmic therapeutics and improve the lives of individuals with eye disorders.

Weight: 1154g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030763664
Edition number: 1st ed. 2021