Opioids

Our Neurobiology of Addiction series provides a comprehensive summary of the most important findings in the neurobiological mechanisms of addiction, with Volume 4 focusing on opioid addiction.

Format: Paperback / softback
Length: 350 pages
Publication date: 01 May 2023
Publisher: Elsevier Science Publishing Co Inc

Our Neurobiology of Addiction series provides a comprehensive survey and synthesis of the most significant findings in our understanding of the neurobiological mechanisms of addiction. Spanning multiple volumes, each dedicated to a specific area of addiction, the series delves into the intricate details of opioid addiction. In Volume 4, titled "Opioids," we employ a heuristic three-stage cycle framework to explore the molecular, cellular, and systems-level factors that contribute to opioid addiction. This framework encompasses the phases of binge/intoxication, withdrawal/negative affect, and preoccupation/anticipation, providing a holistic understanding of the addiction process.

The molecular mechanisms underlying opioid addiction are intricately examined in Volume 4. We explore the role of neurotransmitters, such as dopamine, serotonin, and norepinephrine, in the rewarding and reinforcing effects of opioids. We also delve into the genetic and epigenetic factors that contribute to opioid addiction risk and resilience.

Cellular mechanisms play a crucial role in opioid addiction. We examine the changes in brain structure and function that occur as a result of opioid use, including alterations in reward processing, motivation, and stress response. We also explore the role of immune cells and inflammation in the development and progression of opioid addiction.

Systems-level factors also contribute to opioid addiction. We explore the interactions between the brain, the immune system, and other bodily systems, such as the gastrointestinal and cardiovascular systems. We also examine the social and environmental factors that contribute to opioid addiction, including the impact of social networks, stress, and trauma.

By integrating knowledge from multiple disciplines, including neuroscience, genetics, psychology, and medicine, Volume 4 of the Neurobiology of Addiction series provides a comprehensive understanding of opioid addiction. This knowledge is essential for developing effective treatment strategies and interventions for individuals struggling with opioid addiction.

In conclusion, our Neurobiology of Addiction series offers a valuable resource for researchers, healthcare professionals, and individuals seeking to gain a deeper understanding of the neurobiological mechanisms of addiction. Volume 4, specifically focused on opioids, provides a comprehensive exploration of the molecular, cellular, and systems-level factors that contribute to opioid addiction. By integrating knowledge from multiple disciplines, we can better understand the complexities of this disease and work towards developing effective treatment strategies and interventions to help individuals overcome addiction and lead healthy lives.

Dimension: 235 x 191 (mm)
ISBN-13: 9780128169889