Organocatalytic Dynamic Kinetic Resolution

Dynamic kinetic resolution (DKR) is a novel resolution procedure that exceeds the 50% theoretical yield of classical kinetic resolution by combining the resolution step with an in-situ racemization of the chirally-labile substrate. Chiral green organocatalysts have been demonstrated to promote DKRs, expanding the synthetic scope of the concept. This book provides a comprehensive resource for academics and industrialists interested in green enantioselective catalytic reactions.

Format: Hardback
Length: 158 pages
Publication date: 06 May 2022
Publisher: Royal Society of Chemistry

In a classical kinetic resolution, two enantiomers of a racemate undergo transformation into chiral products at varying rates, with a maximum theoretical yield of 50%. However, the drive to minimize costs and waste in synthesis has spurred the development of novel resolution procedures that surpass this 50% limit. This transformation has given rise to dynamic kinetic resolution (DKR), a method that enables the quantitative yield of one of the enantiomers. DKR combines the resolution step of kinetic resolution with an in-situ racemization of the chirally-labile substrate. It has only been in the past two decades that chiral green organocatalysts have been proven capable of significantly promoting DKRs, expanding the synthetic scope of this powerful concept.

Collecting all the advancements in the field of DKR, this book showcases that a diverse range of organocatalysts enables excellent levels of stereocontrol and yields in various types of transformations. It serves as a valuable resource for academics and industrialists interested in green enantioselective catalytic reactions.

Weight: 378g
Dimension: 234 x 156 (mm)
ISBN-13: 9781839165658