Palladium and Nickel Catalyzed Transformations Forming Functionalized Heterocycles

This book explores Pd- and Ni-catalyzed transformations generating functionalized heterocycles, such as carboiodination, anion-capture cascade, aryl cyanation, and domino processes, highlighting their synthetic utility and mechanistic studies.

Format: Paperback / softback
Length: 212 pages
Publication date: 03 September 2021
Publisher: Springer Nature Switzerland AG

This comprehensive book delves into the realm of Pd- and Ni-catalyzed transformations, leading to the generation of functionalized heterocycles. Transition metal catalysis holds a pivotal position in synthetic organic chemistry, providing innovative and efficient approaches to forge carbon-carbon bonds, thereby contributing to the advancement of this field.

Chapter 1 initiates the exploration by introducing the Pd- and Ni-catalyzed cycloisomerization of aryl iodides to alkyl iodides, a process known as carboiodination. Within the context of the Pd-catalyzed variant, the chapter delves into the synthesis of enantioenriched carboxamides through diastereoselective Pd-catalyzed carboiodination. It further discusses Ni-catalyzed reactions that yield oxindoles and an enantioselective variant utilizing a dual ligand system.

Chapter 2 takes readers on a journey into a Pd-catalyzed diastereoselective anion-capture cascade. It also examines diastereoselective Pd-catalyzed aryl cyanation, a method that generates high yields of borylated chromans as a single diastereomer, showcasing its significant synthetic utility.

Chapter 3 presents a Pd-catalyzed domino process that harnesses carbopalladation, C–H activation, and π-system insertion (benzynes and alkynes) to generate spirocycles. Additionally, it outlines the mechanistic studies conducted on these reactions, providing valuable insights into the underlying mechanisms.

Through these chapters, the book offers a comprehensive and in-depth exploration of Pd- and Ni-catalyzed transformations, paving the way for the development of new and transformative synthetic methodologies in organic chemistry.

Weight: 379g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030540791
Edition number: 1st ed. 2020