Peripheral Nerve Tissue Engineering and Regeneration

This book provides an accessible overview of the current state of nerve repair research, covering biomaterials, therapeutic cells, drug, gene, and extracellular vesicle therapies, research models, and clinical translation. It is written for researchers and clinicians and will be updated as new technologies emerge.

Format: Hardback
Length: 612 pages
Publication date: 26 May 2022
Publisher: Springer Nature Switzerland AG

This comprehensive and accessible book offers a thorough overview of the current state-of-the-art in nerve repair research. It provides a historical background of nerve repair research and introduces key concepts and terminology. The book is organized into five sections: biomaterials, therapeutic cells, drug, gene, and extracellular vesicle therapies, research models, and clinical translation. Each section comprises 3-6 chapters, covering a wide range of relevant technologies. The multidisciplinary approach of the book reflects the field's emphasis on collaboration between different disciplines, such as biomaterials, therapeutic cells, and drug therapies. The chapters are written in an accessible manner, making them suitable for researchers and clinicians from various academic, industrial, and healthcare settings. The book's updatable nature ensures that it can adapt to future changes and new technologies in the field. The primary audience for this work includes researchers and clinicians interested in nerve repair and regenerative medicine.

Introduction:
The field of nerve repair has seen significant advancements in recent years, driven by the need for effective treatments for nerve injuries. This book aims to provide a comprehensive and accessible overview of the current state-of-the-art in nerve repair research.

History of Nerve Repair Research:
The history of nerve repair research dates back to the early 20th century, when scientists began to explore the possibility of regenerating damaged nerve fibers. Since then, significant progress has been made in understanding the mechanisms of nerve injury and developing novel therapeutic strategies.

Key Concepts and Terminology:
In order to facilitate understanding of the field, this book introduces key concepts and terminology related to nerve repair. These include biomaterials, therapeutic cells, drug, gene, and extracellular vesicle therapies, research models, and clinical translation. Each of these sections will be discussed in detail in subsequent chapters.

Biomaterials:
Biomaterials are essential components of nerve repair strategies. They are designed to support the growth and regeneration of nerve fibers. Biomaterials can be classified into two main categories: synthetic and natural. Synthetic biomaterials, such as polymeric materials, are often used due to their ability to mimic the properties of natural tissue. Natural biomaterials, such as collagen and nerve growth factor, are derived from natural sources and have been shown to promote nerve regeneration.

Therapeutic Cells:
Therapeutic cells are another important component of nerve repair strategies. These cells are used to promote nerve regeneration and repair. Therapeutic cells can be derived from various sources, including stem cells and progenitor cells. Stem cells, in particular, have shown great promise in nerve repair due to their ability to differentiate into multiple cell types and their potential for self-renewal.

Drug, Gene, and Extracellular Vesicle Therapies:
Drug, gene, and extracellular vesicle therapies are emerging as promising approaches for nerve repair. These therapies involve the use of drugs, genes, or extracellular vesicles to promote nerve regeneration and repair. Drug therapies involve the use of pharmacological agents to stimulate nerve growth and repair. Gene therapies involve the introduction of genes into damaged nerve fibers to promote their regeneration. Extracellular vesicle therapies involve the use of extracellular vesicles, which are small particles that carry molecules and signals between cells, to promote nerve regeneration and repair.

Research Models:
Research models are essential tools in nerve repair research. These models allow researchers to study the mechanisms of nerve injury and test the efficacy of novel therapeutic strategies. Research models can be classified into two main categories: in vitro models and in vivo models. In vitro models involve the use of cells and tissues in a laboratory setting, while in vivo models involve the use of animals to study nerve injury and repair.

Clinical Translation:
Clinical translation is the process of translating research findings from the laboratory to the clinical setting. It involves the development of safe and effective therapies for patients with nerve injuries. Clinical translation is a critical step in advancing the field of nerve repair and improving patient outcomes.

Conclusion:
This book provides a comprehensive and accessible overview of the current state-of-the-art in nerve repair research. It brings together diverse disciplines under one overarching theme, reflecting the multidisciplinary approach that underpins modern tissue engineering and regenerative medicine. The book is written in an accessible manner, making it suitable for researchers and clinicians from various academic, industrial, and healthcare settings. The updatable nature of the work ensures that it can evolve to accommodate future changes and new technologies in the field. The primary audience for this work includes researchers and clinicians interested in nerve repair and regenerative medicine.

Weight: 1280g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030210519
Edition number: 1st ed. 2022