Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity.  The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles.  This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Format: Hardback
Length: 438 pages
Publication date: 08 March 2022
Publisher: Springer Nature Switzerland AG

The recent advancements in various aspects of pharmacokinetic/pharmacodynamic (PK/PD) methods and the development of nanoparticles for novel drug delivery systems have garnered significant attention in the field of pharmaceutical research. Despite the lack of a consolidated published reference that specifically addresses the PK/PD study of nanoparticle drug delivery systems, this book fills the gap by providing a comprehensive exploration of the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of numerous drugs that exhibit challenges in metabolism or achieve desired therapeutic effects with minimal toxicity.

The authors offer a comprehensive overview of biodistribution, with a particular emphasis on polymer and lipid nanoparticles. This thorough reference is structured into three parts: Modelling, Specific Carriers, and their Potential to Treat Specific Diseases.

In the first part, the authors delve into the theoretical foundations and modelling approaches employed in PK/PD studies of NPDDS. They discuss the use of computational methods, such as molecular dynamics simulations, to predict the drug release profiles, biodistribution, and pharmacological effects of nanoparticles. The authors also highlight the importance of considering the physicochemical properties of nanoparticles, such as size, shape, surface charge, and hydrophobicity, in influencing their interactions with biological systems.

The second part focuses on specific carriers used in NPDDS, including polymers, lipids, and proteins. The authors provide an in-depth analysis of the properties and characteristics of these carriers, including their biocompatibility, stability, and drug loading capacity. They discuss the advantages and disadvantages of each carrier type and explore their potential applications in drug delivery, such as targeted drug delivery, controlled release, and enhanced permeability and retention.

The third part of the book explores the potential of NPDDS to treat specific diseases. The authors discuss the use of nanoparticles for the delivery of therapeutic agents to targeted tissues or cells, with a particular emphasis on cancer therapy. They highlight the advantages of nanoparticle-based drug delivery, such as increased drug concentration at the target site, reduced systemic toxicity, and improved patient compliance. The authors also provide examples of successful nanoparticle-based drug delivery systems in the treatment of cancer, including chemotherapy, radiotherapy, and immunotherapy.

In conclusion, this book serves as a valuable resource for researchers, pharmacists, and medical professionals interested in the PK/PD study of nanoparticle drug delivery systems. It provides a comprehensive overview of the advantages, challenges, and potential applications of NPDDS in enhancing drug efficacy and safety. The authors' expertise in the field and their extensive research make this book an essential addition to the literature on pharmaceutical research and drug delivery.

Weight: 1048g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030833947
Edition number: 1st ed. 2022