Pheno-phospholipids and Lipo-phenolics: Novel Structured Antioxidants

Natural phenolics are powerful bioactive compounds, but their use as antioxidant agents in lipid-based foodstuffs and cosmetics is limited due to their hydrophilic traits. Lipophilization with phospholipids in a suitable solvent to form phenolics-enriched phospholipids (pheno-phospholipids) is a promising technique to enhance their amphiphilic traits and bioavailability. Functional phenolics-enriched phospholipids (pheno-phospholipids) play an important role in enhancing the functional properties of both phenolic compounds and phospholipids in food for their use in nutrition and health. Phenolipids have also found applications in niche sectors such as cosmetics and pharmaceutics, as well as in the novel food.

Format: Paperback / softback
Length: 66 pages
Publication date: 17 February 2022
Publisher: Springer Nature Switzerland AG

Natural phenolics are a class of powerful bioactive compounds, but their use as antioxidant agents in lipid-based foodstuffs and cosmetics is limited due to their hydrophilic nature. To overcome this challenge, researchers have explored various techniques to enhance the hydrophobicity of phenolics, which can improve their solubility and stability in lipid environments. One promising approach is grafting lipophilic moieties onto phenolics to form lipid-enriched phenolics (lipo-phenolics). This process involves attaching hydrophobic chains, such as fatty acids or hydrocarbons, to the phenolic core, resulting in compounds with increased lipophilicity. Lipophilization with phospholipids in a suitable solvent is another method used to enhance the amphiphilic traits of phenolics. This process involves incorporating phospholipids into the phenolic structure, creating phenolics-enriched phospholipids (pheno-phospholipids). Pheno-phospholipids possess both lipophilic and hydrophilic properties, making them highly bioavailable and effective antioxidants.

Functionalized phenolics (phenolipids) have gained significant attention in recent years due to their potential health benefits. These compounds are enriched with phenolic compounds and phospholipids, which together provide a wide range of functional properties. Phenolipids have been shown to exhibit strong antioxidative activity, anti-inflammatory properties, and anticancer effects. They also have the ability to improve lipid metabolism, regulate blood pressure, and promote heart health.

In addition to their functional properties, phenolipids have found applications in various industries. They are used in food supplements, functional foods, and cosmetics as natural preservatives and antioxidants. Phenolipids are also used in pharmaceutical formulations as drug delivery systems and as ingredients in topical creams and lotions.

Recent advances in lipophilization techniques have opened up new opportunities for the development of lipid-enriched phenolics and pheno-phospholipids. These techniques allow for the modification of molecules with high potency and targeted action, covering a wide spectrum of bioactivities. For example, lipophilized phenolics can be used to enhance the bioavailability of drugs, while pheno-phospholipids can be used to target specific cells or tissues for therapeutic purposes.

In conclusion, natural phenolics are a valuable class of bioactive compounds with significant antioxidant and functional properties. However, their hydrophilic nature limits their use in lipid-based foodstuffs and cosmetics. By enhancing the hydrophobicity of phenolics through grafting or lipophilization, researchers have developed lipid-enriched phenolics and pheno-phospholipids that exhibit high bioavailability and antioxidative potential. These functionalized compounds have found applications in various industries, including food, pharmaceuticals, and cosmetics, and have the potential to improve human health and well-being.

Weight: 142g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030674014
Edition number: 1st ed. 2021