Philosophy of Developmental Biology

Developmental biology has been intertwined with debates about whether mechanistic explanations are possible or if alternative explanatory principles or vital forces need to be assumed. This element examines how developmental biology, having turned molecular about four decades ago, has been able to meet the vitalist challenge and discusses the nature and significance of key concepts such as organizers, signals, and morphogens. It also highlights the usefulness of causal knowledge for further scientific discovery.

Format: Paperback / softback
Length: 75 pages
Publication date: 21 April 2022
Publisher: Cambridge University Press

The intricate tapestry of developmental biology is intricately woven with ongoing discussions surrounding the viability of mechanistic explanations for the intricate processes of development. These debates delve into the realm of whether alternative explanatory frameworks, or even the notion of vital forces, must be embraced to fully comprehend the complexities of embryogenesis. One particularly perplexing aspect that has sparked intense scrutiny is the remarkable ability exhibited by embryonic cells to precisely adjust their developmental trajectory based on their relative position within the embryo and the overall size of the developing organism. In the past, mechanistic interpretations struggled to account for this seemingly enigmatic phenomenon. Taking a causal approach, this Element delves into the extent to which developmental biology, having transitioned towards a molecular perspective approximately four decades ago, has been able to confront and overcome the vitalist challenge. It explores not only the nature of explanations but also the invaluable utility of causal knowledge, encompassing the insights gained from classical experimental embryology, in propelling further scientific discoveries. Furthermore, it sheds light on how adopting a causal perspective enables us to comprehend the essence and profound significance of key concepts such as organizers, signals, and morphogens. This title is also accessible as Open Access on Cambridge Core, providing seamless access to its content for researchers, scholars, and the broader scientific community.

Weight: 131g
ISBN-13: 9781108949354