Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharmaceutical Industry

The second edition of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations: Principles, Methods, and Applications in the Pharma Industry is an essential resource for practitioners in the pharmaceutical sciences, providing comprehensive coverage of the field and highlighting its potential for improving drug discovery and development.

Format: Hardback
Length: 624 pages
Publication date: 14 December 2021
Publisher: John Wiley and Sons Ltd

Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations is a comprehensive and authoritative book that delves into the emerging field of physiologically based pharmacokinetic modeling (PBPK). Written by Sheila Annie Peters, a renowned expert in the field, this second edition has been extensively revised to provide up-to-date information and insights into PBPK modeling and simulations.

The book serves as a valuable resource for researchers, scientists, and practitioners in the pharmaceutical industry, as well as students and educators interested in drug discovery and pharmacokinetics.

In its first chapter, the book provides a comprehensive introduction to PBPK modeling, covering its principles, methods, and applications. Peters explains how PBPK modeling can be used to predict the pharmacokinetic behavior of drugs in humans, including absorption, distribution, metabolism, and excretion. She also discusses the importance of considering physiological factors such as body size, gender, age, and genetic variations in drug disposition.

The second chapter delves into the theoretical foundations of PBPK modeling, including mathematical models, computational techniques, and data analysis. Peters explains the different types of PBPK models available, such as compartmental models, semi-mechanistic models, and physiologically based models, and highlights the strengths and limitations of each model. She also discusses the importance of selecting the appropriate model for a specific drug development project.

The third chapter explores the practical aspects of PBPK modeling and simulations, including model development, parameterization, and validation. Peters provides step.

The fourth chapter discusses the applications of PBPK modeling and simulations in drug discovery and development. Peters highlights the importance of PBPK modeling in early drug discovery, where it can be used to identify potential drug candidates, optimize drug formulations, and predict drug safety and efficacy. She also discusses the use of PBPK modeling in drug development, where it can be used to support regulatory filings, optimize clinical trial designs, and monitor drug safety during clinical trials.

The fifth chapter explores the use of PBPK modeling in personalized medicine and drug response prediction. Peters discusses how PBPK modeling can be used to tailor drug dosing and treatment regimens to individual patients, based on their physiological characteristics and genetic makeup. She also highlights the potential of PBPK modeling in predicting drug-drug interactions and adverse drug reactions.

The sixth chapter discusses the challenges and limitations of PBPK modeling and simulations. Peters discusses the need for accurate and reliable data, the complexity of physiological systems, and the challenges associated with model validation and uncertainty quantification. She also provides recommendations for addressing these challenges and improving the accuracy and reliability of PBPK modeling.

The seventh chapter explores the future of PBPK modeling and simulations. Peters discusses the emerging trends in the field, such as the use of artificial intelligence and machine learning in PBPK modeling, the integration of PBPK modeling with other modeling approaches, and the use of PBPK modeling in drug discovery for rare diseases.

The eighth chapter provides a comprehensive reference list of books, articles, and websites related to PBPK modeling and simulations. Peters includes references to both primary sources and secondary sources, allowing readers to further explore the field and stay up-to-date with the latest developments.

In conclusion, Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulations is a must-read for anyone interested in drug discovery and pharmacokinetics. Written by a renowned expert in the field, this second edition provides comprehensive and up-to-date coverage of PBPK modeling and simulations, including its principles, methods, and applications. The book is well-organized, accessible, and filled with valuable insights and case studies that will help readers understand the potential of PBPK modeling in improving drug discovery and development. Whether you are a researcher, scientist, or practitioner, this book will be an invaluable resource for your work.

Weight: 994g
Dimension: 238 x 151 x 38 (mm)
ISBN-13: 9781119497684
Edition number: 2nd Edition