Precision Medicine in Neurodegenerative Disorders: Part I

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology discusses the approach to slow the progression of accelerated brain aging. It covers different models of precision medicine, the lumping-versus-splitting tension in biomarker development, and the rationale for replacing the convergence of autopsy-based nosology with a systems biology approach.

Format: Hardback
Length: 288 pages
Publication date: 28 June 2023
Publisher: Elsevier - Health Sciences Division

Precision Medicine in Neurodegenerative Disorders, Part One, Volume 192 in the Handbook of Clinical Neurology delves into the rationale behind the approach to slow the progression of accelerated brain aging. This comprehensive volume aims to provide a scholarly foundation on the framework, basic science, and conceptual challenges associated with disease-modifying efforts in Parkinson's, Alzheimer's, and other neurodegenerative disorders. Among the topics explored are various models of precision medicine, the tension between lumping and splitting in biomarker development and therapeutics, and the rationale for transitioning from the convergence of the prevailing autopsy-based nosology of neurodegenerative diseases to the divergence of a systems biology approach to human diseases.

Specific chapters are dedicated to the promise of genetic subtypes and the lessons in disease modification offered by the fields of oncology and cystic fibrosis that can be adapted to the field of neurodegeneration. Matching a biology-correcting therapy with those biologically suitable to benefit from such therapy represents the vision and mission of precision medicine, the pinnacle of personalized medicine.

Dimension: 262 x 192 (mm)
ISBN-13: 9780323855389