Prions and Diseases

Transmissible spongiform encephalopathies (TSE), also known as prion diseases, have been recognized for centuries in animals and humans. Modern studies, such as PMCA, have advanced our understanding of their pathogenesis and facilitated the identification of new diseases. The second edition of Prions and Diseases, authored by over 60 leading researchers and clinicians, provides an up-to-date discussion of these unique infectious pathogens and their associated diseases, covering etiology, pathogenesis, classification, histopathology, and clinical aspects. It also covers emerging topics such as inherited human prion disease, stem-cell models, surveillance, and gene therapy strategies.

Format: Hardback
Length: 793 pages
Publication date: 02 January 2023
Publisher: Springer International Publishing AG

Transmissible spongiform encephalopathies (TSE), commonly referred to as prion diseases, have been acknowledged for nearly three centuries in animals and nearly a century in humans. Recent advancements in modern studies, particularly the protein-misfolding cyclic amplification (PMCA), have significantly deepened our comprehension of the mechanisms underlying prion diseases and facilitated the identification of novel prion diseases in both animals and humans. In the second edition of Prions and Diseases, an esteemed panel of over 60 esteemed researchers and clinicians from across the globe convenes to present a comprehensive and timely exploration of these enigmatic infectious pathogens and their associated disorders. This authoritative text serves as a valuable resource, offering up-to-date insights into the etiology, pathogenesis, classification, histopathological characteristics, and clinical manifestations of a wide spectrum of animal and human prion diseases. As a result, it stands as the most comprehensive and authoritative compendium on the past, present, and future of prions and prion diseases. The new second edition delves into crucial emerging topics such as inherited human prion disease, stem-cell models in prion research, human prion disease surveillance, and gene therapy strategies.

Weight: 1370g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031205644
Edition number: 2nd ed. 2023