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Process Intensification in the Manufacturing of Biotherapeutics
Process Intensification in the Manufacturing of Biotherapeutics
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Process Intensification in the Manufacturing of Biotherapeutics, Volume 59 in the Advances in Chemical Engineering series, highlights new advances in the field, such as Evolution and design of continuous bioreactors for the production of biologics, Continuous countercurrent chromatography for the downstream processing of bioproducts, Application of multicolumn countercurrent solvent gradient purification to the polishing of therapeutic proteins, Continuous precipitation technologies for the recovery of bioproducts, Continuous Recovery and Purification of Bioproducts on the Basis of Adsorption Technology, and more.
Format: Hardback
Length: 318 pages
Publication date: 01 July 2022
Publisher: Elsevier Science & Technology
The manufacturing of biotherapeutics is a complex and ever-evolving field, and recent advancements in process intensification have played a crucial role in improving the production of these life-saving drugs. In this comprehensive volume, titled "Process Intensification in the Manufacturing of Biotherapeutics, Volume 59 in the Advances in Chemical Engineering series," readers will find a wealth of information on the latest developments in this field.
The book begins with an insightful chapter that explores the evolution and design of continuous bioreactors for the production of biologics. Continuous bioreactors are a key technology in biopharmaceutical manufacturing, as they allow for the efficient and scalable production of biologics on a large scale. The chapter discusses the different types of continuous bioreactors available, their advantages, and their applications in various industries.
Another interesting chapter focuses on continuous countercurrent chromatography for the downstream processing of bioproducts. This technology is used to purify and concentrate bioproducts from complex mixtures, such as cell cultures or fermentation broth. The chapter discusses the principles of continuous countercurrent chromatography, the different types of columns used, and their applications in various industries.
The application of multicolumn countercurrent solvent gradient purification to the polishing of therapeutic proteins is another important topic covered in the book. This technology is used to improve the purity and yield of therapeutic proteins, which are essential for the development of new drugs. The chapter discusses the different types of purification techniques used, the optimization of purification conditions, and the challenges associated with this technology.
Continuous precipitation technologies for the recovery of bioproducts are also discussed in the book. These technologies are used to separate and recover bioproducts from complex mixtures, such as cell cultures or fermentation broth. The chapter discusses the different types of precipitation techniques available, their advantages, and their applications in various industries.
Continuous Recovery and Purification of Bioproducts on the Basis of Adsorption Technology is another important chapter that explores the use of adsorption technology in the manufacturing of biotherapeutics. Adsorption technology is a cost-effective and efficient method for the purification of bioproducts, as it can be used to remove impurities and contaminants from a mixture. The chapter discusses the different types of adsorbents used, the optimization of adsorption conditions, and the challenges associated with this technology.
The book also includes a chapter on the General Platform for Development of Integrated Continuous Downstream Processes. This chapter discusses the development of integrated continuous downstream processes that can improve the efficiency and productivity of biopharmaceutical manufacturing. The chapter discusses the different types of technologies used in integrated continuous downstream processes, the optimization of process parameters, and the challenges associated with this technology.
In addition to these chapters, the book also includes a comprehensive bibliography that provides readers with further information on the topics discussed in the book.
Overall, "Process Intensification in the Manufacturing of Biotherapeutics, Volume 59 in the Advances in Chemical Engineering series" is a valuable resource for researchers, scientists, and engineers working in the field of biopharmaceutical manufacturing. The book provides a comprehensive overview of the latest advancements in process intensification, and it will be of great interest to anyone who wants to stay up-to-date with the latest developments in this field.
The manufacturing of biotherapeutics is a complex and ever-evolving field, and recent advancements in process intensification have played a crucial role in improving the production of these life-saving drugs. In this comprehensive volume, titled "Process Intensification in the Manufacturing of Biotherapeutics, Volume 59 in the Advances in Chemical Engineering series," readers will find a wealth of information on the latest developments in this field.
The book begins with an insightful chapter that explores the evolution and design of continuous bioreactors for the production of biologics. Continuous bioreactors are a key technology in biopharmaceutical manufacturing, as they allow for the efficient and scalable production of biologics on a large scale. The chapter discusses the different types of continuous bioreactors available, their advantages, and their applications in various industries.
Another interesting chapter focuses on continuous countercurrent chromatography for the downstream processing of bioproducts. This technology is used to purify and concentrate bioproducts from complex mixtures, such as cell cultures or fermentation broth. The chapter discusses the principles of continuous countercurrent chromatography, the different types of columns used, and their applications in various industries.
The application of multicolumn countercurrent solvent gradient purification to the polishing of therapeutic proteins is another important topic covered in the book. This technology is used to improve the purity and yield of therapeutic proteins, which are essential for the development of new drugs. The chapter discusses the different types of purification techniques used, the optimization of purification conditions, and the challenges associated with this technology.
Continuous precipitation technologies for the recovery of bioproducts are also discussed in the book. These technologies are used to separate and recover bioproducts from complex mixtures, such as cell cultures or fermentation broth. The chapter discusses the different types of precipitation techniques available, their advantages, and their applications in various industries.
Continuous Recovery and Purification of Bioproducts on the Basis of Adsorption Technology is another important chapter that explores the use of adsorption technology in the manufacturing of biotherapeutics. Adsorption technology is a cost-effective and efficient method for the purification of bioproducts, as it can be used to remove impurities and contaminants from a mixture. The chapter discusses the different types of adsorbents used, the optimization of adsorption conditions, and the challenges associated with this technology.
The book also includes a chapter on the General Platform for Development of Integrated Continuous Downstream Processes. This chapter discusses the development of integrated continuous downstream processes that can improve the efficiency and productivity of biopharmaceutical manufacturing. The chapter discusses the different types of technologies used in integrated continuous downstream processes, the optimization of process parameters, and the challenges associated with this technology.
In addition to these chapters, the book also includes a comprehensive bibliography that provides readers with further information on the topics discussed in the book.
Overall, "Process Intensification in the Manufacturing of Biotherapeutics, Volume 59 in the Advances in Chemical Engineering series" is a valuable resource for researchers, scientists, and engineers working in the field of biopharmaceutical manufacturing. The book provides a comprehensive overview of the latest advancements in process intensification, and it will be of great interest to anyone who wants to stay up-to-date with the latest developments in this field.
Dimension: 229 x 152 (mm)
ISBN-13: 9780323913553
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