Profiles of Drug Substances, Excipients, and Related Methodology

Volume 49 of Profiles of Drug Substances, Excipients, and Related Methodology provides comprehensive information on drug substances, excipients, and related methodology, including physical, analytical, ADME, and chemical synthesis profiles, as well as profiles of five drug compounds. It also includes a chapter on regulation and standardization of herbal drugs.

Format: Hardback
Length: 454 pages
Publication date: 29 February 2024
Publisher: Elsevier Science Publishing Co Inc

Profiles of Drug Substances, Excipients, and Related Methodology, Volume 49 is a comprehensive and timely resource that provides valuable insights into a wide range of contemporary topics related to drug substances, excipients, and related methodologies. This volume offers a comprehensive overview of physical, analytical, ADME (absorption, distribution, metabolism, and excretion), and methodology-related profiles of drug substances and excipients. It also includes detailed profiles of five drug compounds: Deferasirox, Duvelisib, Regorafenib, Ponatinib, and Avanafil. Furthermore, the book includes a chapter dedicated to the regulation and standardization of herbal drugs, exploring their current status, limitations, challenges, and future prospects.

Physical Profiles of Drug Substances and Excipients:
This section provides detailed information on the physical properties and characteristics of drug substances and excipients, including their appearance, color, density, solubility, and melting point. It also discusses the methods used to measure and characterize these properties, such as spectroscopic analysis, chromatography, and thermal analysis.

Analytical Profiles of Drug Substances and Excipients:
This section focuses on the analytical methods employed to identify, quantify, and characterize drug substances and excipients in various matrices, such as biological fluids, pharmaceutical formulations, and environmental samples. It covers techniques such as high-performance liquid chromatography (HPLC), gas chromatography (GC), mass spectrometry (MS), and immunoassay.

ADME Profiles of Drug Substances and Excipients:
ADME profiles assess the absorption, distribution, metabolism, and excretion of drug substances and excipients in the body. It involves studying the interactions between the drug and biological tissues, including the liver, kidneys, and gastrointestinal tract. This information is crucial for predicting the pharmacokinetic properties of drugs and optimizing their dosage and administration.

Methodology Related to the Characterization of Drug Substances and Excipients:
This section explores the various methodologies used to characterize drug substances and excipients, including physicochemical properties, chemical composition, purity, and stability. It discusses the techniques used to evaluate the safety and efficacy of drug products, such as in vitro and in vivo studies, clinical trials, and post-marketing surveillance.

Methods of Chemical Synthesis:
This section provides an overview of the methods used to synthesize drug substances and excipients, including organic synthesis, semi-synthesis, and total synthesis. It discusses the principles and techniques involved in these processes, as well as the tools and equipment used in drug discovery and development.

Comprehensive Profiles of Five Drug Compounds:
In addition to the aforementioned sections, Profiles of Drug Substances, Excipients, and Related Methodology, Volume 49 includes comprehensive profiles of five drug compounds: Deferasirox, Duvelisib, Regorafenib, Ponatinib, and Avanafil. These profiles provide detailed information on the chemical structure, pharmacological properties, clinical applications, and regulatory considerations of each drug compound.

Regulation and Standardization of Herbal Drugs:
The final chapter of the book focuses on the regulation and standardization of herbal drugs. It explores the current status of herbal drug regulation in different countries, the challenges faced in ensuring the quality and safety of herbal products, and the potential future prospects for the development and regulation of herbal medicines.

In conclusion, Profiles of Drug Substances, Excipients, and Related Methodology, Volume 49 is a valuable resource for researchers, scientists, pharmacists, and healthcare professionals involved in drug discovery, development, and regulation. It provides comprehensive and up-to-date information on a wide range of topics related to drug substances, excipients, and related methodologies, helping to advance our understanding of drug development and improve patient care.

Weight: 450g
Dimension: 229 x 152 (mm)
ISBN-13: 9780443293269