Reactive Oxygen Species in Biology and Human Health

Reactive Oxygen Species in Biology and Human Health is a comprehensive book that provides a detailed overview of ROS, their production, detection, and impact on human diseases. It discusses the role of antioxidants and other compounds in combating oxidative stress and covers various diseases, including neurodegenerative disorders, autoimmune diseases, cancers, cardiovascular diseases, and others.

Format: Paperback / softback
Length: 584 pages
Publication date: 13 June 2022
Publisher: Taylor & Francis Ltd

Reactive Oxygen Species in Biology and Human Health stands out as a comprehensive and insightful exploration of the realm of reactive oxygen species (ROS). Unlike other narrowly focused texts, this book offers a comprehensive overview of ROS, encompassing their current status in research and providing valuable insights into future research directions. Moreover, it authoritatively delves into the profound impact of ROS on various human diseases, shedding light on the role of antioxidants and other compounds in counteracting oxidative stress.

The book is organized into seven sections, each dedicated to exploring different aspects of ROS. The first section introduces ROS, emphasizing their introduction, detection, and production, particularly focusing on the role of phenolic compounds and vitamin E as powerful antioxidants. It also sheds light on the significance of lipoprotein-associated oxidative stress.

Section two delves into the intricate relationship between iron accumulation in the brain and the development of a group of neurodegenerative disorders known as neurodegeneration with brain iron accumulation (NBIA). It identifies several causative genes associated with Parkinsonism-related disorders and highlights the importance of iron in the brain's functioning.

Section three explores a diverse range of neurodegenerative disorders, including amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD), Huntington's disease (HD), epilepsy, and multiple sclerosis (MS). It provides detailed accounts of these conditions, their symptoms, and the current understanding of their underlying mechanisms.

Section four examines the role of ROS in the development of autoimmune diseases, such as asthma, autoimmune liver diseases, rheumatoid arthritis, thyroid disease, primary biliary cirrhosis, and systemic lupus. It explores the complex interplay between ROS and immune system dysfunction, shedding light on potential treatment strategies.

Section five analyzes the impact of ROS on various types of cancer, including lung cancer, breast cancer, and melanoma. It discusses the mechanisms by which ROS promote cancer cell growth and survival, as well as the potential benefits of antioxidants and other compounds in cancer prevention and treatment.

Section six explores the relationship between ROS and cardiovascular diseases (CVDs). It highlights the complex biochemical processes that lead to inflammation, a major contributor to CVDs. It also discusses the roles of carotenoids in preventing CVDs and the importance of maintaining a healthy lifestyle to mitigate ROS-induced damage.

The final section addresses other human diseases influenced by ROS, including diabetes, chronic obstructive pulmonary disease (COPD), and aging-related disorders. It explores the mechanisms by which ROS contribute to these diseases and the potential for interventions to mitigate their effects.

Reactive Oxygen Species in Biology and Human Health is a valuable resource for researchers, medical professionals, and anyone interested in understanding the complex interplay between ROS and human health. With its comprehensive coverage, authoritative insights, and insightful discussions, this book provides a deep understanding of ROS and their implications for our well-being.

Dimension: 254 x 178 (mm)
ISBN-13: 9781032339979