Recent Developments in the Synthesis and Applications of Pyridines

Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook that covers synthetic methods, applications, and computational chemistry of pyridines, bridging the gap between industry and academia.

Format: Paperback / softback
Length: 648 pages
Publication date: 30 September 2022
Publisher: Elsevier - Health Sciences Division

Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook for organic chemists working on innovative approaches to the synthesis of pyridines. Written by scientists in both academia and industry and designed to be a standalone reference, the book features reviews, research results, and case studies on synthetic methods and applications of pyridine-based chemotypes. The book will bridge the gap between industry and academia by presenting recent innovative approaches to the synthesis of pyridines, diverse applications of pyridines in drug development, heterogeneous catalysis and material science, as well as benchtop to shelf narratives of pyridine-based compounds in the industry. The role of computational chemistry in the development of pyridine-based bioactive molecules is also included. This reference is essential for researchers in organic chemistry both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry.

Pyridines are a class of organic compounds that have been widely studied due to their diverse range of properties and applications. In recent years, there has been a significant increase in research and development in the synthesis and applications of pyridines, driven by the need for new drugs, materials, and catalysts. This handbook provides a comprehensive overview of the latest developments in the field, covering topics such as synthetic methods, reaction mechanisms, and applications in drug discovery, catalysis, and materials science.

One of the key areas of research in pyridine synthesis is the development of efficient and selective methods for the construction of complex pyridine-based molecules. These methods include organocatalysis, which involves the use of organic catalysts to promote chemical reactions, and click chemistry, which involves the use of short, stable bonds to assemble complex molecules. Organocatalysis has been particularly successful in the synthesis of complex pyridine-based pharmaceuticals, while click chemistry has been used to develop new materials with unique properties.

Another important area of research in pyridine applications is drug discovery. Pyridines have been used as lead compounds in the development of a wide range of drugs, including antibiotics, anticancer agents, and antiviral agents. Recent advances in drug discovery have focused on the development of new pyridine-based compounds that are more selective and have fewer side effects. For example, some pyridine-based drugs have been shown to be effective in treating drug-resistant infections, while others have been developed as anticancer agents that target specific cancer cells.

In addition to drug discovery, pyridines have also been used in catalysis and materials science. Pyridine-based catalysts have been used in the synthesis of a wide range of chemicals, including pharmaceuticals, polymers, and fuels. Pyridine-based materials have been used in a variety of applications, including electronics, energy storage, and environmental remediation. For example, pyridine-based polymers have been used in the development of flexible electronic devices, while pyridine-based catalysts have been used in the synthesis of biofuels.

Finally, the role of computational chemistry in the development of pyridine-based bioactive molecules is also discussed in this handbook. Computational chemistry is a powerful tool that allows researchers to predict the properties and behavior of molecules before they are synthesized. This has been particularly useful in the development of new pyridine-based drugs and materials, as it allows researchers to identify potential lead compounds and optimize their properties.

In conclusion, Recent Developments in the Synthesis and Applications of Pyridines is a comprehensive handbook that provides a detailed overview of the latest developments in the field of pyridine synthesis and applications. The book covers topics such as synthetic methods, reaction mechanisms, and applications in drug discovery, catalysis, and materials science. It is essential for researchers in organic chemistry, both in academic and industrial settings, postgraduates in chemistry and medicinal chemistry, and anyone interested in the latest developments in this field.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323912211