Redox Regulation of Differentiation and De-differentiation

Redox regulation is essential for cell differentiation and the development of multicellular organisms. It involves the modification of single cysteines, which regulate stem cell differentiation, organ formation, and cancer cell de-differentiation. Current cancer therapy is based on redox events, and regeneration often reactivates developmental pathways. This book summarizes the roles of redox regulation in development by bringing together different concepts and comparing similarities and differences between various cell types and species. It highlights the potential of redox medicine and combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration.

Format: Paperback / softback
Length: 380 pages
Publication date: 29 January 2024
Publisher: Taylor & Francis Ltd

Cell differentiation and the emergence of multicellular organisms are intricate processes driven by signaling molecules and cascades, including redox regulation. These reactions played a crucial role in the early stages of life's evolution by providing the necessary energy for metabolic processes. Today, redox modifications are recognized as vital regulatory events in various cellular functions, including differentiation and development. Redox modifications of single cysteines play a pivotal role in regulating stem cell differentiation, organ formation, and de-differentiation, such as the development of cancer cells.

Cancer therapy, in particular, relies on redox events, and regenerative processes often reawaken developmental pathways. Understanding the molecular mechanisms of differentiation and de-differentiation is essential for advancing the development of new medical therapies.

This book aims to provide a comprehensive summary of the roles of redox regulation in development by bringing together diverse concepts and comparing similarities and differences across different cell types and species. An international team of contributors presents several novel aspects of redox-regulated differentiation and de-differentiation, encompassing areas of redox medicine.

Key Features:

Provides a comprehensive overview of redox regulation in development
Reviews the redox-dependent development of model organisms and single organs
Highlights the redox-regulated pathways essential for differentiation processes
Illustrates the potential applications of redox medicine
Combines state-of-the-art knowledge in differentiation/development, aging/longevity, and repair/regeneration
Written by renowned experts in the field

Related Titles:

Ayyanathan, K., ed. Cancer Cell Signaling: Targeting Signaling Pathways Toward Therapeutic Approac.

Weight: 453g
Dimension: 254 x 178 (mm)
ISBN-13: 9781032068428