Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal

Format: Hardback
Length: 350 pages
Publication date: 01 August 2023
Publisher: Elsevier Science Publishing Co Inc

Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal is a comprehensive and authoritative book that delves into the intricate world of resistance to anti-CD20 antibodies and explores innovative strategies for their reversal. Written by esteemed international experts in the field, this book offers in-depth insights and cutting-edge knowledge on this critical topic.

Anti-CD20 antibodies, which are designed to deplete B cells and treat B cell proliferative disorders such as non-Hodgkins lymphoma and chronic lymphocytic leukemia, have revolutionized the treatment of B cell malignancies in the past two decades. However, despite their effectiveness, there are patients who fail to respond to initial therapy or experience relapse sooner. This book aims to address these challenges by exploring new and existing avenues surrounding anti-CD20 antibodies.

One of the key areas of focus in this book is the development of next-generation anti-CD20 therapies. While these therapies have shown promising results in treating B cell malignancies, predicting and reversing resistance remains a significant challenge. The book discusses in detail the mechanisms of resistance to anti-CD20 antibodies, including genetic mutations, epigenetic modifications, and immune cell crosstalk. It also highlights the importance of understanding these mechanisms in order to develop more effective and targeted therapies.

Another important aspect of the book is the exploration of novel approaches for reversing resistance to anti-CD20 antibodies. This includes the use of combination therapies, targeted therapies, and immunomodulators. The book discusses the potential benefits and risks of these approaches, as well as the clinical trials that are currently underway to evaluate their effectiveness.

In addition to its scientific content, Resistance to Anti-CD20 Antibodies and Approaches for Their Reversal is a valuable resource for researchers, students, and members of the biomedical and medical fields. It provides a comprehensive overview of the current state of knowledge in this field, and serves as a reference for future research and clinical practice.

Overall, this book is a must-read for anyone interested in the study of resistance to anti-CD20 antibodies and approaches for their reversal. It offers a wealth of information and insights that will be valuable to researchers, clinicians, and patients alike.

Dimension: 234 x 191 (mm)
ISBN-13: 9780443192005