Sample Sizes for Clinical Trials

Sample Sizes for Clinical Trials,Second Edition is a practical book that helps researchers estimate the sample size for clinical trials. It provides detailed worked examples and covers various objectives,trial designs,and pitfalls. The book is aimed at researchers and practitioners and could be used for teaching purposes.

Format: Hardback
Length: 396 pages
Publication date: 21 June 2023
Publisher: Taylor & Francis Ltd

Sample Sizes for Clinical Trials,Second Edition is a comprehensive and practical guide that assists researchers in estimating the appropriate sample size for clinical trials. Throughout the book, detailed worked examples are provided to illustrate both the calculations and their presentation to colleagues or in protocols. Additionally, the book highlights some common pitfalls in sample size calculations and the key steps that lead to the final determination.

The book offers comprehensive coverage of sample size calculations, including data from Normal, binary, ordinal, and survival outcomes. It covers various study objectives such as superiority, equivalence, non-inferiority, bioequivalence, and precision, both for parallel group and crossover designs. The text emphasizes how trial objectives influence the study design, affecting the derivation of sample formulae and the overall size of the study. Real-life clinical trials are used to demonstrate the application of the calculations, providing practical insights into the process.

In the updated second edition, all chapters have been revised extensively, with some chapters undergoing substantial revisions. Additionally, four new chapters have been added, covering topics such as multiplicity, cluster trials, pilot studies, and single-arm trials. This expanded coverage ensures that researchers and practitioners have access to the latest information and techniques in sample size calculations.

The book is primarily aimed at researchers and practitioners involved in clinical trials and biostatistics. It serves as a valuable resource for teaching courses on sample size calculations, providing a comprehensive and systematic approach to the topic. By providing clear explanations, worked examples, and tables, Sample Sizes for Clinical Trials,Second Edition empowers researchers to make informed decisions regarding the design and execution of clinical trials, ensuring the validity and reliability of their findings.

In conclusion, Sample Sizes for Clinical Trials,Second Edition is a must-have resource for researchers and practitioners seeking to estimate the appropriate sample size for clinical trials. With its comprehensive coverage, practical examples, and insightful guidance, this book empowers researchers to design and execute high-quality clinical trials that yield meaningful results.

Weight: 906g
Dimension: 184 x 261 x 29 (mm)
ISBN-13: 9781138587892
Edition number: 2 ed