Senescence, Senotherapeutics and Mitochondria

Senescence,Senotherapeutics, and Mitochondria, Volume 136 provides updates on cellular senescence, mitochondria-associated cellular senescence mechanisms, and potential senotheraputics. It also covers phytotherapeutic targeting of the mitochondria in neurodegenerative disorders and the use of melatonin as a mitochondria-targeted drug.

Format: Hardback
Length: 264 pages
Publication date: 01 July 2023
Publisher: Elsevier Science Publishing Co Inc

Senescence, Senotherapeutics, and Mitochondria, Volume 136, is a comprehensive resource that provides up-to-date insights into these fascinating topics. The book is divided into several chapters, each dedicated to exploring different aspects of cellular senescence, mitochondria, and their roles in aging and disease.

Cellular Senescence in Aging: Molecular Basis, Implications, and Therapeutic Interventions

This chapter delves into the molecular mechanisms underlying cellular senescence, including the role of telomeres, DNA damage, and oxidative stress. It discusses the implications of cellular senescence in aging and the development of age-related diseases such as cancer, Alzheimer's, and Parkinson's. The chapter also highlights potential therapeutic interventions, such as senolytic drugs and mitochondrial modulation, that aim to slow down or reverse the process of cellular senescence.

Mitochondria-associated Cellular Senescence Mechanisms: Biochemical and Pharmacological Perspectives

This chapter explores the biochemical and pharmacological mechanisms that contribute to mitochondrial-associated cellular senescence. It discusses the role of mitochondria in generating ATP, regulating cellular metabolism, and generating reactive oxygen species (ROS). The chapter also explores the potential use of drugs and natural compounds to target mitochondrial dysfunction and mitigate cellular senescence.

Mitochondria in Cell Senescence: Friend or Foe?

This chapter examines the controversial role of mitochondria in cell senescence. While some studies suggest that mitochondria play a critical role in promoting cellular senescence, others argue that they may be protective against the process. The chapter discusses the latest research on the relationship between mitochondria and cell senescence and explores the potential use of mitochondrial-targeted therapies to mitigate senescence-associated diseases.

The Role of Mitochondria and Mitophagy in Cell Senescence

This chapter explores the role of mitochondria and mitophagy in cell senescence. Mitophagy is a process by which damaged or dysfunctional mitochondria are cleared from the cell, and it is believed to play a critical role in maintaining cellular homeostasis and preventing senescence. The chapter discusses the latest research on the mechanisms of mitophagy and its potential use as a therapeutic intervention in aging and disease.

Small Molecules Targeting Mitochondrial Dysfunction for Potential Senotheraputics

This chapter discusses the use of small molecules to target mitochondrial dysfunction and mitigate cellular senescence. It discusses the potential use of drugs and natural compounds that modulate mitochondrial function, such as antioxidants, anti-inflammatory agents, and mitochondrial biogenesis regulators. The chapter also highlights the challenges and limitations of using small molecules as senotherapeutics and discusses the need for further research to develop more effective and safe treatments.

Senolytic and Senomorphic Interventions to Defy Senescence-associated Mitochondrial Dysfunction

This chapter explores the use of senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction. Senolytic drugs are designed to target and degrade senescent cells, while senomorphic drugs are designed to promote the repair and regeneration of damaged cells. The chapter discusses the latest research on the mechanisms of senolysis and senomorphosis and their potential use as therapeutic interventions in aging and disease.

Mitochondrial Targeting Peptides and Probes

This chapter discusses the use of mitochondrial targeting peptides and probes as tools for studying mitochondrial function and identifying potential therapeutic targets. Mitochondrial targeting peptides are designed to deliver drugs or other molecules specifically to mitochondria, while probes are used to detect and measure mitochondrial activity. The chapter highlights the latest research on the development of mitochondrial targeting peptides and probes and their potential use in aging and disease.

Mitochondria-derived Peptides in Healthy Aging and Therapy of Age-related Diseases

This chapter explores the use of mitochondria-derived peptides as potential therapeutics for aging and age-related diseases. Mitochondria-derived peptides are small proteins that are produced by mitochondria and have been shown to have various biological activities, including anti-inflammatory, antioxidant, and anti-aging effects. The chapter discusses the latest research on the development of mitochondria-derived peptides as potential treatments for Alzheimer's, Parkinson's, and other age-related diseases.

Other Sections Covering Targeting of Mitostasis-Proteostasis Axis by Antioxidant Polysaccharides in Neurodegeneration

This section discusses the use of antioxidant polysaccharides to target the mitostasis-proteostasis axis in neurodegeneration. Mitostasis is the balance between the synthesis and degradation of proteins, and proteostasis is the regulation of protein folding and stability. Neurodegenerative disorders, such as Alzheimer's and Parkinson's, are characterized by imbalances in these pathways, which contribute to the development and progression of the disease. The section highlights the latest research on the use of antioxidant polysaccharides as potential therapeutics for neurodegenerative disorders.

Phytotherapeutic Targeting of the Mitochondria in Neurodegenerative Disorders

This section discusses the use of phytotherapeutics to target the mitochondria in neurodegenerative disorders. Phytotherapeutics are natural compounds derived from plants that have been shown to have therapeutic effects on various diseases, including neurodegenerative disorders. The section highlights the latest research on the use of phytotherapeutics as potential treatments for Alzheimer's, Parkinson's, and other neurodegenerative disorders.

Melatonin as Mitochondria-Targeted Drugs

This section discusses the use of melatonin as a mitochondria-targeted drug for the treatment of aging and age-related diseases. Melatonin is a natural hormone that is produced by the pineal gland and has been shown to have various anti-aging and anti-inflammatory effects. The section highlights the latest research on the use of melatonin as a potential treatment for Alzheimer's, Parkinson's, and other age-related diseases.

Coenzyme Q-related Compounds to Maintain Healthy Mitochondria during Aging

This section discusses the use of coenzyme Q-related compounds to maintain healthy mitochondria during aging. Coenzyme Q is a natural compound that is found in the mitochondria and is involved in the production of ATP. The section highlights the latest research on the use of coenzyme Q-related compounds as potential treatments for aging and age-related diseases.

Changing ROS, NAD, and AMP: a Path to Longevity via Mitochondrial Therapeutics

This section discusses the use of mitochondrial therapeutics as a potential path to longevity. Mitochondria are the powerhouses of the cell, and they play a critical role in regulating cellular metabolism, generating energy, and generating reactive oxygen species (ROS). The section highlights the latest research on the use of mitochondrial therapeutics as potential treatments for aging and age-related diseases.

In conclusion, Senescence, Senotherapeutics, and Mitochondria, Volume 136, is a comprehensive resource that provides up-to-date insights into cellular senescence, mitochondria, and their roles in aging and disease. The book is divided into several chapters, each dedicated to exploring different aspects of these topics. The chapters cover a wide range of topics, including the molecular mechanisms underlying cellular senescence, the biochemical and pharmacological mechanisms that contribute to mitochondrial-associated cellular senescence, the controversial role of mitochondria in cell senescence, the role of mitochondria and mitophagy in cell senescence, the use of small molecules to target mitochondrial dysfunction for potential senotheraputics, senolytic and senomorphic interventions to defy senescence-associated mitochondrial dysfunction, the use of mitochondrial targeting peptides and probes, the use of mitochondria-derived peptides in healthy aging and therapy of age-related diseases, and other sections covering targeting of mitostasis-proteostasis axis by antioxidant polysaccharides in neurodegeneration, phytotherapeutic targeting of the mitochondria in neurodegenerative disorders, melatonin as mitochondria-targeted drugs, coenzyme Q-related compounds to maintain healthy mitochondria during aging, changing ROS, NAD, and AMP: a path to longevity via mitochondrial therapeutics, and more. The book is written by leading experts in the field and is an essential resource for researchers, clinicians, and anyone interested in understanding the role of cellular senescence, mitochondria, and their potential therapeutic applications in aging and disease.

Dimension: 229 x 151 (mm)
ISBN-13: 9780443188862