Sleep and Clocks in Aging and Longevity

This edited volume explores the interplay between sleep and circadian rhythms with health, aging, and longevity, emphasizing the importance of understanding the bidirectional relationship between sleep and biological clocks for optimal health. The book covers various topics such as sleep and clock interlink in health and longevity, sleep, aging, and longevity, melatonin, sleep, and clock, genetic regulation of sleep and clock, therapeutic interventions in sleep disorders, and experimental models to study sleep and clocks in aging and longevity. It is useful for advanced undergraduate and graduate students, researchers, educators, and biomedical professionals.

Format: Hardback
Length: 561 pages
Publication date: 07 March 2023
Publisher: Springer International Publishing AG

This edited volume delves into the intricate interplay between sleep and circadian rhythms, shedding light on their profound impact on health, aging, and longevity. Recognizing the indispensable role of sleep in human well-being, it highlights the detrimental consequences of insufficient sleep, including reduced quality of life, increased susceptibility to diseases, and premature mortality. The sleep-wake cycle, a fundamental neurobiological phenomenon conserved across species, serves as a prominent manifestation of the biological clocks located in the suprachiasmatic nucleus (SCN). Understanding the bidirectional relationship between sleep and circadian rhythms is of utmost importance and urgency, particularly in the context of modern lifestyles characterized by sleep disturbances, social jetlag, artificial lighting, and other factors that disrupt our natural rhythms.

The book comprises 25 chapters authored by renowned researchers and experts from 11 countries, meticulously organized into seven sections:

Understanding Sleep and Clock Interlink in Health and Longevity: This section explores the fundamental mechanisms by which sleep and circadian rhythms influence health and longevity. It examines the role of sleep in immune function, metabolism, cardiovascular health, and cognitive performance.

Sleep, Aging, and Longevity: This section examines the relationship between sleep and aging, exploring the mechanisms underlying sleep disturbances, such as insomnia and sleep apnea, in the aging process. It also discusses the potential benefits of sleep interventions for promoting healthy aging and longevity.

Clock, Aging, and Longevity: This section explores the role of the biological clock in aging and longevity. It discusses the mechanisms by which the clock regulates cellular processes, including metabolism, inflammation, and immune function, and the implications of clock misalignment for health and longevity.

Melatonin, Sleep, and Clock: This section explores the role of melatonin, the natural hormone secreted by the pineal gland, in regulating sleep and circadian rhythms. It discusses the effects of melatonin supplementation on sleep quality, circadian timing, and overall health.

Genetic Regulation of Sleep and Clock: This section examines the genetic factors that influence sleep and circadian rhythms. It discusses the role of single-nucleotide polymorphisms (SNPs) and epigenetic modifications in determining sleep patterns and the risk of sleep disorders.

Therapeutic Interventions in Sleep Disorders and Clock Misalignment: This section explores the therapeutic approaches for addressing sleep disorders, such as insomnia and sleep apnea, and restoring clock misalignment. It discusses the use of medications, lifestyle modifications, and cognitive-behavioral therapies to improve sleep quality and promote healthy circadian rhythms.

Experimental Models to Study Sleep and Clocks in Aging and Longevity: This section presents experimental models that help us understand the mechanisms underlying sleep and circadian rhythms in aging and longevity. It discusses the use of animal models, human clinical studies, and advanced technologies to study the effects of sleep deprivation, circadian disruption, and other factors on health and longevity.

This book is a valuable resource for advanced undergraduate and graduate students, researchers, educators, and other biomedical professionals interested in understanding the complex relationship between sleep and circadian rhythms. It provides a comprehensive and up-to-date overview of the current knowledge in this field, covering a wide range of topics and offering insights into potential therapeutic interventions and future research directions. By unraveling the secrets of sleep and circadian rhythms, this book contributes to our understanding of human health and well-being, paving the way for improved sleep practices, targeted interventions, and enhanced longevity.

Weight: 1016g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031224676
Edition number: 1st ed. 2023