Surface Plasmon Resonance in Bioanalysis

Surface Plasmon Resonance in Bioanalysis, Volume 95 covers applications and advances in SPR, including single-cell drug screening, imaging, and biorefinery technology.

Format: Hardback
Length: 424 pages
Publication date: 04 November 2021
Publisher: Elsevier - Health Sciences Division

Surface Plasmon Resonance (SPR) is a powerful analytical technique that has found widespread applications in bioanalysis, particularly in the field of single-cell based drug screening. In this comprehensive volume, published in the Comprehensive Analytical Chemistry series, researchers and scientists explore the latest advancements and diverse applications of SPR in bioanalysis.

Chapter 1 provides an introduction to surface plasmon resonance, covering its principles, instrumentation, and applications in bioanalysis. It discusses the use of SPR for the detection and characterization of biomolecules, such as proteins, nucleic acids, and small molecules. The chapter also highlights the advantages of SPR over other analytical techniques, such as chromatography and mass spectrometry.

Chapter 2 explores the use of Surface Plasmon Resonance Microscopy (SPRM) for single-cell based drug screening. SPRM enables the rapid and sensitive analysis of individual cells, allowing researchers to identify and quantify the presence of drugs and other molecules within cells. The chapter discusses the development of SPRM platforms, the optimization of imaging conditions, and the application of SPRM in drug discovery and development.

Chapter 3 focuses on Phase-Sensitive Surface Plasmon Resonance Sensors for Highly Sensitive Bioanalysis. These sensors utilize the phase shift of SPR signals to detect and quantify small changes in the binding affinity of biomolecules. The chapter discusses the development of phase-sensitive SPR sensors, their applications in drug discovery, and their potential for personalized medicine.

Chapter 4 explores the use of SPR coupled to ambient mass spectrometry for the analysis of complex biological samples. SPR-MS enables the simultaneous detection and identification of multiple biomolecules in a single sample, providing comprehensive information about the biological composition of the sample. The chapter discusses the development of SPR-MS platforms, the optimization of mass spectrometry parameters, and the application of SPR-MS in drug discovery and toxicology.

Chapter 5 explores Surface Plasmon Resonance Microscopy for activity detection and imaging of single cells. SPRM enables the real-time monitoring of cellular activities, such as protein synthesis, cell division, and cell signaling. The chapter discusses the development of SPRM platforms, the optimization of imaging conditions, and the application of SPRM in cell biology and medicine.

Chapter 6 focuses on SPR for water pollutant detection and biofouling control. SPR enables the sensitive and specific detection of water pollutants, such as pesticides, pharmaceuticals, and personal care products. The chapter discusses the development of SPR sensors, the optimization of detection conditions, and the application of SPR in environmental monitoring and water treatment.

Chapter 7 explores SPR imaging for cellular analysis and detection. SPR imaging enables the visualization of cellular structures and activities in three dimensions. The chapter discusses the development of SPR imaging platforms, the optimization of imaging conditions, and the application of SPR imaging in cell biology, medicine, and pathology.

Chapter 8 discusses Progress in detection of surface palsmon resonance for biorefinery technology. SPR is used in biorefinery processes to monitor and optimize the production of biofuels and other bioproducts. The chapter discusses the development of SPR sensors, the optimization of detection conditions, and the application of SPR in biorefinery processes.

Chapter 9 covers Long-range surface plasmon resonance and its biological sensing applications. Long-range SPR enables the detection of interactions between biomolecules at a distance, providing insights into molecular interactions and biological processes. The chapter discusses the development of long-range SPR platforms, the optimization of sensing conditions, and the application of long-range SPR in drug discovery, biomedicine, and environmental monitoring.

Chapter 10 addresses Critical issues in clinical and biomedical applications of Surface Plasmon Resonance sensing. Surface Plasmon Resonance is used in clinical diagnostics and therapeutics to detect and analyze biomarkers and disease markers. The chapter discusses the development of Surface Plasmon Resonance sensors, the optimization of sensing conditions, and the application of Surface Plasmon Resonance in clinical diagnostics, drug discovery, and personalized medicine.

In conclusion, Surface Plasmon Resonance in Bioanalysis, Volume 95 is a valuable resource for researchers and scientists interested in exploring the latest advancements and diverse applications of SPR in bioanalysis. The book covers a wide range of topics, from single-cell based drug screening to environmental monitoring, and provides comprehensive insights into the principles, instrumentation, and applications of SPR. The chapters are written by experts in the field, and the book is well-illustrated with examples and figures to enhance understanding. Whether you are a student, researcher, or professional in the bioanalytical field, this book will be a valuable addition to your library.

Weight: 1000g
Dimension: 229 x 152 (mm)
ISBN-13: 9780323853095