Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumor Biology

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology categorizes imaging and targeting approaches according to cancer type, highlighting new and safe approaches involving membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells. This multidisciplinary book bridges the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging, making it suitable for researchers in oncology and bioengineering.

Format: Paperback / softback
Length: 216 pages
Publication date: 01 December 2021
Publisher: Elsevier Science Publishing Co Inc

Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology is a comprehensive review that explores innovative imaging and targeting approaches for cancer diagnosis and treatment. The book categorizes these approaches based on cancer types, highlighting novel and safe strategies involving membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells. The ultimate goal is to develop precise targeting and multifunctional nanotechnology-based imaging probes that can improve cancer detection, characterization, and treatment.

This book is highly multidisciplinary, bridging the knowledge gap between tumor biology, nanotechnology, and diagnostic imaging. It is suitable for researchers from various fields, including oncology and bioengineering. Despite significant advancements in cancer diagnosis, treatment, and management in recent decades, the current therapeutic options remain insufficient, leading to high mortality and morbidity rates. Early detection remains one of the most promising avenues for substantial improvement. Recent developments in nanotechnology hold the potential to enhance our understanding of tumor biology, enabling the development of nanomaterials for targeted imaging and therapy in both in vitro and in vivo experimental models.

Membrane-coated nanoparticles are a promising approach for cancer imaging and therapy. These nanoparticles can be designed to target specific cancer cells or tissues and can be loaded with therapeutic agents or imaging agents. For example, liposomes, which are lipid bilayers, can be used to encapsulate drugs or imaging agents and target cancer cells. Another example is gold nanoparticles, which have excellent photothermal properties and can be used for hyperthermia therapy or imaging-guided cancer treatment.

Tumor cell-derived extracellular vesicles are another promising approach for cancer imaging and therapy. These vesicles are secreted by cancer cells and contain various biomolecules, including proteins, lipids, and nucleic acids. They can be used to deliver therapeutic agents directly to cancer cells or to deliver imaging agents to specific regions of the body. For example, exosomes can be used to deliver drugs or imaging agents to tumor cells, while microvesicles can be used to deliver imaging agents to the lymphatic system.

Circulating tumor cells are a unique type of cancer cell that can be detected and targeted using various imaging techniques. These cells are shed from primary tumors into the bloodstream and can travel to distant organs, where they can form secondary tumors. Circulating tumor cells can be detected using techniques such as flow cytometry, which separates cells based on their size, shape, and fluorescence properties. Circulating tumor cells can also be targeted using antibodies or other ligands that bind to specific markers on the surface of the cells.

Cell-free DNAs are a promising approach for cancer diagnosis and therapy. These DNA fragments are released into the bloodstream by cancer cells and can be detected using techniques such as PCR or next-generation sequencing. Cell-free DNAs can be used to detect cancer at an early stage, before symptoms develop, and can be used to monitor cancer progression and response to therapy.

Cancer stem cells are a subset of cancer cells that have the ability to self-renew and differentiate into various cell types. They are believed to be responsible for the recurrence and metastasis of cancer. Cancer stem cells can be targeted using various imaging techniques, such as fluorescence in situ hybridization (FISH) or immunohistochemistry. Cancer stem cells can also be targeted using drugs or other therapies that specifically target these cells.

In conclusion, Targeted Cancer Imaging: Design and Synthesis of Nanoplatforms based on Tumour Biology provides a comprehensive review of innovative imaging and targeting approaches for cancer diagnosis and treatment. The book highlights novel and safe strategies involving membrane-coated nanoparticles, tumor cell-derived extracellular vesicles, circulating tumor cells, cell-free DNAs, and cancer stem cells. These approaches have the potential to improve cancer detection, characterization, and treatment, leading to better outcomes for patients with cancer. As nanotechnology continues to advance, we can expect to see more precise and multifunctional nanotechnology-based imaging probes developed for cancer diagnosis and therapy.

Weight: 362g
Dimension: 152 x 329 x 19 (mm)
ISBN-13: 9780128245132