TDP-43 and Neurodegeneration: From Bench to Bedside

Aggregates of the TAR DNA binding protein 43 (TDP-43) are hallmark features of ALS and FTD, with overlapping clinical, genetic, and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies, including autophagy-mediated therapy, stress granule role, genetic models, cell culture-based models, systems biology for precision medicine, stem cell development, and mechanism-based therapies for ALS and other related neurodegenerative diseases.

Format: Paperback / softback
Length: 270 pages
Publication date: 27 October 2021
Publisher: Elsevier Science Publishing Co Inc

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic, and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43s structure, function, biology, misfolding, aggregation, pathogenesis, and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells, and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND), and other neurodegenerative disorders.

Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic, and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43s structure, function, biology, misfolding, aggregation, pathogenesis, and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture-based models, systems biology for precision medicine, development of stem cells, and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND), and other neurodegenerative disorders.

Weight: 446g
Dimension: 154 x 228 x 18 (mm)
ISBN-13: 9780128200667