The Folate Story: A vitamin under the microscope

Folate, or vitamin B9, has been discovered by Lucy Wills and is essential for preventing birth defects such as spina bifida. However, scandals such as opposition to women becoming doctors, lack of recognition, and incorrect use of folic acid have led to thousands of babies being born with spina bifida each year.

Format: Paperback / softback
Length: 184 pages
Publication date: 28 February 2023
Publisher: Troubador Publishing

The remarkable tale of folate (vitamin B9) encompasses a series of outstanding achievements that have significantly advanced various fields of medical practice, as well as international scandals of immense significance. Folate stands out as the sole vitamin to have been discovered by a woman, Lucy Wills, who made a groundbreaking discovery in 1931. Through her research, Wills demonstrated that the yeast extract known as Marmite could effectively treat anaemia among pregnant women in Bombay. Not only did folate rectify anaemia, but it also played a crucial role in preventing the birth of babies with the severe defect spina bifida.

The development of effective anti-bacterial and anti-cancer drugs owes its origins to the discovery of folate. The initial anti-folates were instrumental in combating bacterial infections and cancerous growths. However, the story of folate also includes scandals that have tarnished its reputation. One such scandal involves the opposition faced by women seeking medical education and careers, primarily from male-dominated societies. The lack of public recognition and acknowledgment of Lucy Wills' groundbreaking achievements further highlights the gender disparities that existed during her time.

Furthermore, the British Government's treatment of Waldemar Haffkine, the scientist who developed the world's first two anti-bacterial vaccines and saved millions of lives, is a scandalous episode in the story of folate. Haffkine faced immense persecution and discrimination, despite his invaluable contributions to global health. His work was disregarded and his achievements marginalized, reflecting the political and societal complexities of the period.

Another scandal involves the incorrect use of folic acid to treat pernicious anaemia, resulting in irreversible paralysis. This tragic mistake led to a significant loss of lives and underscores the importance of proper medical research and guidelines. The failure of worldwide fortification of the diet with folic acid is perhaps the most significant scandal in the story of folate. This catastrophe allows thousands of babies to be born each year with the major birth defect spina bifida, a condition that could be easily prevented through the simple and cost-effective measure of fortification. Despite the clear evidence of its effectiveness, many countries have yet to implement mandatory fortification policies, resulting in a needless loss of lives and suffering.

The story of folate is a complex and multifaceted narrative that highlights both the achievements and scandals that have shaped its development and impact on global health. It serves as a reminder of the importance of scientific discovery, gender equality, and public health policies in addressing critical health challenges. As we continue to explore the potential benefits and risks of folate and other vitamins, it is essential to learn from the past and strive for a more equitable and effective approach to healthcare.

Weight: 684g
Dimension: 189 x 249 x 19 (mm)
ISBN-13: 9781803136912