The Immunogenetics of Dermatologic Diseases

This book investigates the genetic changes in immunological processes involved in cutaneous diseases, aiming to find susceptibility genes for complex conditions and generate hypotheses about disease pathogenesis. Immunogenetic studies have revolutionized the management of chronic dermatological conditions like psoriasis, but there are still unanswered questions. Whole genome sequencing strategies could help tailor targeted treatments based on specific genetic backgrounds.

Format: Paperback / softback
Length: 450 pages
Publication date: 16 March 2023
Publisher: Springer Nature Switzerland AG

This book aims to delve into the diverse range of genetic alterations that contribute to immunological processes in cutaneous diseases. One of the primary objectives of immunogenetic research is the identification of susceptibility genes for complex disorders, offering valuable insights into the pathogenesis of these conditions that may not be readily accessible through other methodologies. Consequently, immunogenetic studies serve as a logical starting point for formulating hypotheses regarding disease pathogenesis. This holds particular significance for dermatology, a field characterized by a high prevalence of diseases with unknown etiologies. Through immunogenetic investigations, targeted treatment strategies have become feasible for diseases like psoriasis and pemphigus, revolutionizing the management of chronic dermatological conditions. However, despite these advancements, many questions remain unanswered. For instance, individuals with psoriasis exhibit diverse responses to the commercially available biological agents, highlighting the role of genetic variations in determining treatment outcomes. Whole genome sequencing strategies, if feasible at the individual level, have the potential to tailor these targeted treatments based on specific genetic backgrounds.

Our intention in writing this book was to comprehensively explore the genetic aspects of immunological processes in cutaneous diseases. We have attempted to cover various areas of dermatology where sufficient studies were available to compile chapters. Nevertheless, there exists a significant knowledge gap regarding the immunogenetics of many dermatological conditions. We hope that this book will inspire investigators to address these gaps and contribute to the advancement of our understanding in this field.

Weight: 891g
Dimension: 254 x 178 (mm)
ISBN-13: 9783030926182
Edition number: 1st ed. 2022