The Kirkwood-Buff Theory of Solutions: With Selected Applications to Solvation and Proteins

The Kirkwood-Buff Theory of Solutions is a general theory that can be applied to all possible solutions, including aqueous solutions of proteins and nucleic acids. It was dormant for over 20 years but became extremely useful after the publication of the Inversion of the KB theory in 1978. The book explains all necessary concepts in statistical mechanics in a simple and intuitive way, and provides examples of applications to water, aqueous solutions, protein folding, and self-association of proteins.

Format: Paperback / softback
Length: 212 pages
Publication date: 03 October 2023
Publisher: Elsevier - Health Sciences Division

The Kirkwood-Buff Theory of Solutions: With Selected Applications to Solvation and Proteins is a comprehensive and accessible introduction to the Kirkwood-Buff (KB) Theory of solution,a fundamental concept in thermodynamics. This theory is presented in a straightforward and pedagogical manner, making it accessible to individuals with limited background in thermodynamics. Beyond its significance as a powerful and versatile theory, the KB Theory stands out as the most general framework that can be applied to all possible solutions, including aqueous solutions of proteins and nucleic acids.

The book begins with introductory chapters that provide a solid foundation in chemical thermodynamics and statistical mechanics. These chapters serve as a primer for readers, laying the groundwork for the subsequent derivation and inversion of the KB Theory. Originally published in 1951, the KB theory remained relatively dormant for over two decades. However, its importance was revitalized when author Arieh Ben-Naim published the Inversion of the KB Theory in 1978.

This book serves as an invaluable resource for researchers seeking to solve problems involving mixtures or solutions across different phases. It elucidates all the essential concepts of statistical mechanics featured in the KB Theory in a simple and intuitive manner. By employing the principles outlined in this theory, researchers can effectively address a wide range of problems in the fields of chemistry, physics, and biochemistry.

Several examples of applications of the KB Theory are provided throughout the book. These examples encompass diverse areas such as water, aqueous solutions, protein folding, and self-association of proteins. By examining these applications, readers gain a deeper understanding of the practical implications and potential applications of the KB Theory in various scientific and industrial contexts.

In conclusion, The Kirkwood-Buff Theory of Solutions: With Selected Applications to Solvation and Proteins is a must-read for anyone interested in gaining a deeper understanding of the Kirkwood-Buff Theory of solution and its applications in various scientific disciplines. This book provides a comprehensive and accessible introduction to the theory, while also offering practical insights and examples that illustrate its significance and versatility.

Weight: 450g
Dimension: 229 x 151 (mm)
ISBN-13: 9780443219153