The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part A

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics,Volume Three provides an overview of the historical background, current nosology, and guidelines for Gilles de la Tourette Syndrome. It also covers pathophysiology, neuroimaging, and clinical and neurodevelopmental brain imaging. The last 20 years have seen an exponential growth in research dedicated to the syndrome's genetics and neurobiology, resulting in over 3,000 scientific publications.

Format: Hardback
Length: 422 pages
Publication date: 01 July 2022
Publisher: Elsevier Science & Technology

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics,Volume Three is a comprehensive and detailed exploration of the historical background, current nosology, and guidelines related to this complex neurological disorder. In addition to providing an overview of pathophysiology, the book delves into the genetic basis, neurochemistry, electrophysiology, and widespread neural circuits associated with Tourette Syndrome.

Specific chapters cover various aspects of Tourette Syndrome, including its phenomenology, natural history, and neurobiology. These chapters explore the underlying mechanisms that contribute to the development of tics, motor disorders, and associated cognitive impairments.

The book also includes an update on recent progress in the neurobiology of Tourette Syndrome. It discusses the latest research findings and discoveries that have shed light on the underlying mechanisms of the disorder. This includes discussions on gene expression, neural circuits, and neuroimaging applications, which have played a crucial role in understanding Tourette Syndrome.

Current guidelines and nosology of Tourette Syndrome are also covered in depth. The book provides an overview of the diagnostic criteria and treatment approaches used to manage Tourette Syndrome. It also discusses the challenges and controversies surrounding the diagnosis and treatment of Tourette Syndrome, highlighting the need for further research and collaboration.

Neuroimaging applications in Tourette Syndrome are explored in detail. The book discusses the use of various imaging techniques, such as functional magnetic resonance imaging (fMRI), to study the brain structure and connectivity in individuals with Tourette Syndrome. This information has helped researchers better understand the underlying neurobiological mechanisms and has implications for developing targeted treatments.

Clinical and neurodevelopmental brain imaging of Tourette syndrome is another important topic covered in the book. The authors discuss the use of imaging techniques to evaluate the brain structure and function in individuals with Tourette Syndrome, including those with co-occurring disorders such as attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD). This information has important implications for understanding the neurodevelopmental trajectory of Tourette Syndrome and for developing personalized treatment approaches.

Altered Structural Connectivity in Gilles de la Tourette Syndrome is a fascinating chapter that explores the changes in brain structure and connectivity observed in individuals with Tourette Syndrome. The authors discuss the use of advanced imaging techniques, such as diffusion tensor imaging (DTI), to study the white matter fiber tracts in the brain. This information has helped researchers better understand the underlying neurobiological mechanisms and has implications for developing targeted treatments.

The book also includes a wealth of additional information on Tourette Syndrome, including its historical background, cultural perspectives, and societal implications. It provides a comprehensive and up-to-date overview of this complex neurological disorder, making it an invaluable resource for researchers, clinicians, and individuals affected by Tourette Syndrome.

The last 20 years have witnessed an exponential growth in research dedicated to Gilles de la Tourette Syndrome, driven by a deep understanding of its complex genetics and underlying neurobiology. This remarkable surge in basic and clinical research has led to over 3,000 scientific publications, expanding our knowledge and understanding of Tourette Syndrome in unprecedented ways.

The genetic basis of Tourette Syndrome has been extensively studied, and researchers have identified numerous genetic mutations that are associated with the disorder. These mutations have helped to shed light on the underlying mechanisms that contribute to the development of tics, motor disorders, and associated cognitive impairments. For example, studies have shown that Tourette Syndrome is associated with changes in gene expression, particularly in regions of the brain involved in motor control and reward processing.

Neural circuits have also been a major focus of research in Tourette Syndrome. Studies have shown that the disorder is characterized by abnormal neural activity in regions of the brain involved in motor control, sensory processing, and reward processing. This abnormal activity is thought to contribute to the development of tics and other symptoms of Tourette Syndrome.

Neuroimaging applications have played a crucial role in understanding Tourette Syndrome. Functional magnetic resonance imaging (fMRI) has been used to study the brain structure and connectivity in individuals with Tourette Syndrome. This information has helped researchers better understand the underlying neurobiological mechanisms and has implications for developing targeted treatments. For example, studies have shown that individuals with Tourette Syndrome have abnormal connectivity in regions of the brain involved in motor control and sensory processing, which may contribute to the development of tics.

Clinical and neurodevelopmental brain imaging of Tourette syndrome has also been a significant area of research. Imaging techniques such as diffusion tensor imaging (DTI) have been used to study the white matter fiber tracts in the brain. This information has helped researchers better understand the neurodevelopmental trajectory of Tourette Syndrome and has implications for developing personalized treatment approaches. For example, studies have shown that individuals with Tourette Syndrome may have altered structural connectivity in regions of the brain involved in motor control and sensory processing, which may contribute to the development of co-occurring disorders such as ADHD and ASD.

Altered Structural Connectivity in Gilles de la Tourette Syndrome is a fascinating topic that has emerged in recent years. Researchers have used advanced imaging techniques, such as DTI, to study the changes in brain structure and connectivity observed in individuals with Tourette Syndrome. This information has helped researchers better understand the underlying neurobiological mechanisms and has implications for developing targeted treatments. For example, studies have shown that individuals with Tourette Syndrome may have altered structural connectivity in regions of the brain involved in motor control and sensory processing, which may contribute to the development of co-occurring disorders such as ADHD and ASD.

In conclusion, the Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics,Volume Three is a comprehensive and detailed exploration of the historical background, current nosology, and guidelines related to this complex neurological disorder. The book provides a wealth of information on the genetic basis, neurochemistry, electrophysiology, and widespread neural circuits associated with Tourette Syndrome. It also includes an update on recent progress in the neurobiology of Tourette Syndrome, current guidelines and nosology, neuroimaging applications, clinical and neurodevelopmental brain imaging, and altered structural connectivity. The last 20 years have witnessed an exponential growth in research dedicated to Gilles de la Tourette Syndrome, driven by a deep understanding of its complex genetics and underlying neurobiology. This remarkable surge in basic and clinical research has led to over 3,000 scientific publications, expanding our knowledge and understanding of Tourette Syndrome in unprecedented ways. As we continue to advance our understanding of Tourette Syndrome, we are closer to developing effective treatments and interventions that can improve the lives of individuals affected by this disorder.

Dimension: 229 x 152 (mm)
ISBN-13: 9780323910347