The Neurobiology of the Gilles De La Tourette Syndrome and Chronic Tics: Part B

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four provides an overview of the historical background, current nosology, and guidelines for the study of Tourette Syndrome. It also covers pathophysiology, genetic basis, genome-wide association study, de novo mutations, animal models, neural-immune crosstalk, and functional connectivity.

Format: Hardback
Length: 400 pages
Publication date: 01 September 2022
Publisher: Elsevier Science & Technology

The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four is a comprehensive and detailed exploration of the intricate mechanisms underlying the Gilles de la Tourette Syndrome (GTS) and chronic tics. This extensive review delves into the historical background, current nosology, and guidelines associated with these conditions. Additionally, it provides a comprehensive overview of the pathophysiology of GTS, encompassing a wide range of topics such as its genetic basis, alterations in neurochemistry and electrophysiology, and the intricate neural circuits involved.

The book is organized into several specific chapters, each dedicated to exploring different aspects of GTS and chronic tics. These chapters cover essential topics such as the genetic basis of GTS, genome-wide association studies of Tourette Syndrome, de novo mutations in Tourette Syndrome, animal models for Tourette Syndrome, the neural-immune crosstalk in Tourette syndrome, functional connectivity in the Gilles de la Tourette Syndrome, and many more.

In the first chapter, the authors provide a historical overview of the development of the understanding of GTS and chronic tics. They trace the historical milestones, key discoveries, and breakthroughs that have contributed to our current knowledge of these conditions. This chapter serves as a foundation for the subsequent chapters, providing a context for the detailed discussions that follow.

The second chapter focuses on the current nosology and guidelines for diagnosing and treating GTS and chronic tics. The authors review the diagnostic criteria, classification systems, and treatment approaches used in the field. They discuss the importance of accurate diagnosis and the need for comprehensive treatment plans that address both the physical and psychological aspects of these conditions.

The third chapter delves into the pathophysiology of GTS and chronic tics. The authors provide a comprehensive overview of the genetic basis of these conditions, exploring the role of genes and environmental factors in their development. They discuss the genetic mutations and variations that have been identified in GTS and the potential mechanisms by which they contribute to the symptoms observed.

The fourth chapter explores the alterations in neurochemistry and electrophysiology that occur in GTS. The authors discuss the changes in neurotransmitter levels, brain structure, and neural circuits that are associated with the symptoms of tics and other associated behaviors. They also explore the potential role of neuroimaging techniques in diagnosing and understanding these conditions.

The fifth chapter focuses on the neural circuits involved in GTS and chronic tics. The authors provide a detailed explanation of the brain regions and networks that are implicated in the generation and regulation of tics. They discuss the role of cortical-striatal circuits, basal ganglia, and other brain regions in the development and maintenance of tics.

The sixth chapter explores the neural-immune crosstalk in Tourette syndrome. The authors discuss the interactions between the immune system and the nervous system in the development and progression of GTS. They explore the potential role of immune-mediated mechanisms in the onset and exacerbation of tics and other associated symptoms.

The seventh chapter focuses on functional connectivity in the Gilles de la Tourette Syndrome. The authors provide a detailed analysis of the brain networks that are disrupted in GTS and chronic tics. They discuss the role of functional connectivity in the generation and regulation of tics and other associated behaviors.

The eighth chapter explores the role of environmental factors in the development and maintenance of GTS and chronic tics. The authors discuss the potential influence of parenting styles, social stress, and other environmental factors on the onset and progression of these conditions. They also explore the potential for early intervention and prevention strategies.

The ninth chapter discusses the treatment options for GTS and chronic tics. The authors review the various therapeutic approaches, including medication, behavioral therapy, and cognitive-behavioral therapy. They discuss the benefits and limitations of each treatment approach and the importance of individualized treatment plans that address the unique needs and characteristics of each patient.

The tenth chapter explores the challenges and controversies surrounding the diagnosis and treatment of GTS and chronic tics. The authors discuss the historical stigma associated with these conditions, the challenges faced by patients and their families, and the need for increased awareness and education about these conditions. They also discuss the potential for future research and innovation in the field.

The eleventh chapter provides a conclusion to the book, summarizing the key findings and highlighting the importance of continued research and advocacy in the field of GTS and chronic tics. The authors emphasize the need for interdisciplinary collaboration, patient-centered care, and the development of effective treatment strategies that improve the quality of life for individuals affected by these conditions.

In conclusion, The Neurobiology of the Gilles de la Tourette Syndrome and Chronic Tics, Part B, Volume Four is a comprehensive and detailed exploration of the intricate mechanisms underlying the Gilles de la Tourette Syndrome and chronic tics. This book provides a wealth of information and insights into the pathophysiology, genetic basis, and treatment options for these conditions. It is an essential resource for researchers, clinicians, and individuals affected by GTS and chronic tics, as well as anyone interested in gaining a deeper understanding of these complex neurological disorders.

Weight: 750g
Dimension: 162 x 236 x 28 (mm)
ISBN-13: 9780323910361