The Secret Lives of Transcription Factors: In Heterochromatin Regulation

This SpringerBrief explores the unconventional functions of eight transcription factors and their biological significance, including effects on processes within the cell nucleus during development and in adult organisms.

Format: Paperback / softback
Length: 45 pages
Publication date: 26 April 2023
Publisher: Springer International Publishing AG

This SpringerBrief delves into the diverse roles of eight distinct transcription factors, shedding light on their unconventional functions. It begins by exploring the unconventional activities of GAGA, HP1, Rb, STAT, ATF-2, and NF-kB, highlighting their presence in both heterochromatin and euchromatin contexts. Remarkably, these transcription factors have been shown to exhibit unique functions when associated with heterochromatin.

Chapter Two delves into the unconventional functions of STAT and HP1, emphasizing their roles in promoting longevity, safeguarding against cancer, and mitigating DNA damage. Chapter Three takes a broader perspective, examining the biological significance of the findings presented in Chapters One and Two and considering how global changes in the epigenome, influenced by factors such as STAT and HP1, may impact processes within the cell nucleus during development and in adult organisms.

This concise yet comprehensive SpringerBrief serves as a valuable resource for researchers engaged in epigenetics, as well as instructors teaching the subject. It also appeals to individuals with interests in gene transcription control, cell nucleus processes, and development.

Weight: 120g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031290275
Edition number: 1st ed. 2023