Therapeutic Applications of Dopamine D3 Receptor Function: New Insight After 30 Years Of Research

The CTBN volume Therapeutic Applications of Dopamine D3 Receptor Function reviews the state of knowledge on the dopamine D3 receptor and its role in human behavior and disease, including neuropsychiatric illnesses, addictions, and substance use disorders. It was cloned and characterized almost 25 years ago and is anatomically localized to the limbic circuitry, suggesting a potential contribution to the pathophysiology of these disorders.

Format: Hardback
Length: 275 pages
Publication date: 03 January 2023
Publisher: Springer International Publishing AG

The CTBN volume, Therapeutic Applications of Dopamine D3 Receptor Function, delves into the comprehensive understanding of the dopamine D3 receptor and its profound impact on human behavior and various diseases, including neuropsychiatric illnesses such as schizophrenia, mood disorders, Parkinson's disease, restless legs syndrome, addictions, and substance use disorders. Written by esteemed experts from diverse multidisciplinary fields, including imaging, behavioral testing, clinical trials, and preclinical models/molecular pharmacology, this volume explores the therapeutic potential and implications of the D3 receptor.

The D3 dopamine receptor, belonging to the D2-like family of G protein-coupled receptors, was cloned and characterized approximately 25 years ago. A notable characteristic of the D3 dopamine receptor system is its highly localized anatomical distribution within the limbic circuitry. This has sparked considerable interest, leading to the hypothesis that D3 involvement could contribute to the pathophysiology of neuropsychiatric disorders, encompassing a range of conditions, including but not limited to psychosis, addictions, and substance abuse, as well as mood and movement disorders.

The CTBN volume provides a comprehensive review of the current knowledge on the dopamine D3 receptor, shedding light on its role in human behavior and disease. It serves as a valuable resource for researchers, clinicians, and healthcare professionals seeking to better understand the therapeutic potential of targeting the D3 receptor in the treatment of neuropsychiatric disorders. By bringing together experts from diverse disciplines, this volume fosters interdisciplinary collaboration and advances our understanding of the complex mechanisms underlying these conditions.

Weight: 594g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031230578
Edition number: 1st ed. 2023