Tissue Engineering For Degenerative Intervertebral Discs

The book discusses the fundamentals and recent developments in stem cell therapy and tissue engineering technology for treating intervertebral disc degeneration, offering an alternative to traditional treatment methods.

Format: Hardback
Length: 160 pages
Publication date: 12 April 2019
Publisher: World Scientific Publishing Co Pte Ltd

Low back pain is a prevalent disorder that frequently requires clinical intervention within the Department of Orthopedics. Lumbar intervertebral disc degeneration serves as a primary cause of chronic pain, and the process of reversing this condition is challenging. Traditional treatment approaches encompass both conservative and surgical interventions. While these methods can alleviate some of the clinical symptoms associated with intervertebral disc degeneration, they fail to address the underlying issues and can lead to corresponding complications.

In recent years, the emergence of tissue engineering technology and its diverse applications has brought forth fresh perspectives on the treatment of intervertebral disc degeneration. This book delves into the fundamental principles as well as the most recent advancements in stem cell therapy and tissue engineering technology, presenting an alternative approach to addressing the degeneration of intervertebral discs.

The primary objective of this book is to provide a comprehensive and up-to-date exploration of the latest developments in the field of tissue engineering and stem cell therapy for the treatment of intervertebral disc degeneration. It aims to serve as a valuable resource for healthcare professionals, researchers, and individuals seeking innovative solutions to this prevalent condition.

Chapter 1: Introduction

Intervertebral disc degeneration is a common condition that affects the spine, causing pain, discomfort, and reduced mobility. The lumbar region, particularly the lower back, is particularly susceptible to this condition, which can significantly impact an individual's quality of life.

Traditional treatment methods for intervertebral disc degeneration include conservative treatments such as physical therapy, medication, and lifestyle modifications. However, these methods often provide only temporary relief and do not address the underlying causes of the condition. Surgical interventions, such as disc replacement or fusion, are also available but come with their own set of risks and complications.

In recent years, tissue engineering technology and stem cell therapy have emerged as promising alternatives for treating intervertebral disc degeneration. These approaches offer the potential to regenerate and repair damaged disc tissue, providing long-term relief from pain and improving mobility.

Chapter 2: Fundamentals of Tissue Engineering and Stem Cell Therapy

Tissue engineering is a multidisciplinary field that involves the creation of artificial tissues and organs to replace damaged or diseased natural tissues. Stem cell therapy, on the other hand, involves the use of stem cells to regenerate and repair damaged tissue.

In the context of intervertebral disc degeneration, tissue engineering technology can be used to create artificial discs that mimic the function of natural discs. These discs can be implanted into the spine to replace damaged or degenerated discs, providing pain relief and restoring mobility. Stem cell therapy can be used to regenerate and repair the damaged disc tissue, promoting healing and reducing inflammation.

Chapter 3: Recent Developments in Stem Cell Therapy and Tissue Engineering Technology

Stem cell therapy for intervertebral disc degeneration has made significant progress in recent years. Researchers have identified different types of stem cells that can be used to regenerate and repair disc tissue, including mesenchymal stem cells, adipose-derived stem cells, and umbilical cord-derived stem cells.

In addition, tissue engineering technology has advanced significantly, with the development of new materials and techniques that can improve the efficacy and safety of artificial discs and stem cell therapies. For example, biocompatible materials that mimic the properties of natural disc tissue can be used to create artificial discs that are more durable and less likely to cause inflammation.

Chapter 4: Clinical Applications of Stem Cell Therapy and Tissue Engineering Technology

Stem cell therapy and tissue engineering technology have been successfully applied in clinical trials for the treatment of intervertebral disc degeneration. These trials have demonstrated the potential of these approaches to provide long-term pain relief and improve mobility.

One of the most promising clinical applications of stem cell therapy for intervertebral disc degeneration is the use of stem cells to regenerate and repair damaged disc tissue. This approach has been shown to reduce inflammation, promote healing, and improve the function of the disc. In clinical trials, stem cell therapy has been used to treat patients with disc herniation, disc bulge, and degenerative disc disease.

Tissue engineering technology has also been used to create artificial discs that mimic the function of natural discs. These discs can be implanted into the spine to replace damaged or degenerated discs, providing pain relief and restoring mobility. In clinical trials, artificial discs have been shown to provide similar pain relief and mobility improvements as surgical interventions but with fewer risks and complications.

Chapter 5: Conclusion

Intervertebral disc degeneration is a prevalent condition that can cause significant pain and disability. Traditional treatment methods have limitations, and surgical interventions come with risks and complications.

However, tissue engineering technology and stem cell therapy have emerged as promising alternatives for treating intervertebral disc degeneration. These approaches offer the potential to regenerate and repair damaged disc tissue, providing long-term pain relief and improving mobility.

In conclusion, this book provides a comprehensive and up-to-date exploration of the latest developments in tissue engineering and stem cell therapy for the treatment of intervertebral disc degeneration. It serves as a valuable resource for healthcare professionals, researchers, and individuals seeking innovative solutions to this prevalent condition. By understanding the fundamentals of tissue engineering and stem cell therapy, readers can gain a deeper understanding of the potential benefits and limitations of these approaches and make informed decisions about their treatment options.

Weight: 384g
Dimension: 162 x 237 x 14 (mm)
ISBN-13: 9789813238565