Torsades de Pointes

Torsades de Pointes (TdP) is a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG). This book provides a comprehensive source of information on the topic, including epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management. It is an essential reference for clinicians and researchers, providing guidance for clinicians who care for patients receiving QT interval-prolonging drugs and cutting-edge information for scientists and investigators.

Format: Paperback / softback
Length: 376 pages
Publication date: 25 March 2022
Publisher: Elsevier Science Publishing Co Inc

Over the past 25-30 years, a significant number of drugs have been withdrawn from the market due to the risk of causing Torsades de Pointes (TdP). However, approximately 200 drugs that prolong the QT interval and can lead to TdP remain available. It is alarming that several drugs among the top 200 most prescribed drugs in the US have the potential to cause TdP, and new information about this condition is emerging rapidly. The purpose of this book is to provide a comprehensive and up-to-date resource on TdP, a life-threatening polymorphic ventricular tachyarrhythmia associated with QT interval prolongation on the electrocardiogram (ECG). Torsades de Pointes offers detailed and emerging information related to the epidemiology, drug culprits, mechanisms, risk factors, and methods of prevention and management of this life-threatening polymorphic ventricular tachycardia, also known as torsades de pointes. The book encompasses current knowledge, incorporating recent and cutting-edge advances in understanding topics such as inherited channelopathies and congenital Long QT Syndrome (LQTS); drugs that cause QT interval prolongation and TdP; non-drug causes of acquired QT interval prolongation and TdP; epidemiology of inherited and acquired TdP; morbidity and mortality associated with TdP, particularly in association with specific antimicrobials, antidepressants, antipsychotics, and methadone; cellular and molecular mechanisms of TdP; traditional and emerging risk factors for TdP; methods of prevention and risk reduction for TdP; and clinical management of patients with TdP. This book serves as an essential reference for both clinicians and researchers, providing guidance. It guides. Guidance. Guidance. Guidance. For. Clinicians. Who. Care. For. Patients. Receiving. QT. Interval-Prolonging. Drugs. As. Well. As. Cutting. Edge. Information. For. Researchers. In. The. Field.

Dimension: 276 x 216 (mm)
ISBN-13: 9780128214466