Ureases: Functions, Classes, and Applications

Ureases: Foundations, Classes, and Applications is a comprehensive book that covers the basics, historical research, and current state of ureases, enzymes with nickel in their active sites, and their diverse applications in biotechnological and drug discovery processes.

Format: Paperback / softback
Length: 482 pages
Publication date: 19 February 2024
Publisher: Elsevier Science & Technology

Urease: Foundations, Classes, and Applications is a comprehensive and practical analysis of urease enzymes, which are gaining increasing importance in various biotechnological applications and drug discovery. Unique among enzymes, urease contains nickel in its active sites, making it a fascinating subject of study. This book covers all aspects of urease, from its foundational overview to historical research, current state, and diverse applications in biochemistry, crystallography, and bioinorganic chemistry.

The book begins with a foundational overview, providing a comprehensive understanding of urease's structure, function, and classification. It then delves into historical research, highlighting the contributions of renowned scientists and their discoveries in urease-related fields. The book progresses to discuss the current state of urease research, covering topics such as basic biochemistry, enzymology, crystallography, and bioinorganic chemistry.

The different classes of urease, while structurally diverse, are chemically equivalent and are individually discussed in detail. The multi-protein, multi-step activation of urease, involving chemical modification of residues, transport, and transfer of nickel ions, is examined in depth. The catalytic mechanisms of ureolysis, the breakdown of urea, and the development of inhibitors to control urease activity are explored.

The final two sections of the book address multiple applications of urease in health and biotechnology. The first section focuses on gastric ulcer treatment, highlighting the use of urease-producing bacteria as a potential therapy. The second section explores architectural uses of urease in buildings and engineering, where urease-producing bacteria can be employed to degrade urea and ammonia, reducing odor and improving indoor air quality.

Future applications and next steps in research are also considered. The book emphasizes the potential of urease in various industries, including agriculture, environmental remediation, and pharmaceutical development. It encourages researchers to explore new avenues of research and develop innovative technologies to harness the full potential of urease in various applications.

In conclusion, Urease: Foundations, Classes, and Applications is a valuable resource for researchers, students, and professionals interested in urease enzymes. It provides a thorough and up-to-date analysis of urease's structure, function, and applications, covering a wide range of topics from basic biochemistry to biotechnology. The book's comprehensive coverage and practical insights make it an essential tool for anyone seeking to understand and utilize the power of urease in their research and applications.

Weight: 450g
Dimension: 234 x 191 (mm)
ISBN-13: 9780323918008