Wiring the Nervous System: Mechanisms of Axonal and Dendritic Remodelling in Health and Disease

This book explores recent discoveries on neuronal remodeling in model organisms, including axonal degeneration, morphogenesis, structural plasticity, and degeneration and regeneration. It highlights the progress made in understanding the cellular and molecular mechanisms of neuronal remodeling and its relevance to neurological disorders.

Format: Hardback
Length: 310 pages
Publication date: 31 January 2024
Publisher: River Publishers

This comprehensive book delves into the intricate mechanisms of axonal and dendritic remodeling in various model organisms. Comprising a collection of chapters authored by esteemed experts in their respective neuroscientific subfields, it offers a comprehensive exploration of the latest discoveries in the field. Spanning from neuronal morphogenesis during development to experience-dependent structural plasticity, and encompassing neuronal degeneration, regeneration, and pathologies in neurological disorders, this book provides a deep understanding of the dynamic processes that shape the nervous system.

Axonal degeneration, a crucial process during development and in pathological conditions, is extensively examined. The book sheds light on the cellular and molecular mechanisms that govern this process, shedding new insights into the mechanisms underlying neuronal loss and the potential for regeneration.

Neuronal morphogenesis, the process by which axons and dendrites are formed and shaped, is explored in detail. The authors discuss the molecular mechanisms that regulate this complex process, highlighting the role of growth factors, signaling pathways, and epigenetic regulation in shaping neuronal structure and function.

Experience-dependent structural plasticity, a key feature of the nervous system, is explored in depth. The book discusses how environmental stimuli and behavioral experiences can influence the structural and functional properties of neurons, leading to changes in synaptic connections and cognitive behavior.

Dendrite degeneration and regeneration are also examined, with a focus on the cellular and molecular mechanisms that drive these processes. The authors discuss the role of neurotrophic factors, inflammation, and cellular signaling pathways in promoting dendritic regeneration and restoring neuronal function in pathological conditions.

Furthermore, the book explores the potential applications of these findings in the development of novel therapeutic strategies for neurological disorders. The authors discuss the use of stem cells, gene therapy, and other innovative approaches to promote neuronal repair and regeneration, offering hope for patients suffering from debilitating conditions.

In conclusion, this book is a valuable resource for researchers, students, and clinicians interested in the field of neurosciences. It provides a comprehensive and up-to-date overview of the latest findings on axonal and dendritic remodeling, offering insights into the cellular and molecular mechanisms that control these processes and their implications for understanding and treating neurological disorders.

Weight: 670g
Dimension: 161 x 241 x 21 (mm)
ISBN-13: 9788770228527