Wnt Signaling in Development and Disease

Wnt Signaling in Development and Disease, Volume 153, explores the biology of Wnt signaling in model organisms, covering recent discoveries, interactions, and tools for studying its complexity in various fields.

Format: Hardback
Length: 424 pages
Publication date: 01 April 2023
Publisher: Elsevier Science Publishing Co Inc

Wnt Signaling in Development and Disease,Volume 153, is a comprehensive exploration of the biology of Wnt signaling in a diverse range of model organisms. Since their initial discovery in 1982, Wnt proteins and their downstream effectors have garnered significant attention from researchers across various disciplines, including developmental biology, cell signaling, structural biology, stem and cancer cell biology, and regeneration. Wnt signaling, alongside a select group of highly conserved signaling modules such as the Hedgehog, FGF, BMP, RA, and Notch pathways, plays a pivotal role in orchestrating morphogenesis across all metazoans. This volume provides readers with up-to-date information on recent breakthroughs in the Wnt field, including intricate interactions between Wnt and other signaling pathways, as well as innovative tools and technologies for dissecting the complexity of Wnt signaling.

In addition, other chapters delve into the realm of Wnt signaling during neural development in Xenopus, hematopoietic stem cell development, gut epithelium maintenance and regeneration, skeletal Wnt signaling as a foundation for Wnt-based regenerative medicine, and non-canonical Wnt5a-Ror signaling: Insights from human congenital disorders and cancer.

This comprehensive volume serves as a valuable resource for researchers, students, and clinicians interested in understanding the intricate mechanisms of Wnt signaling and its implications in development, disease, and regenerative medicine.

Dimension: 229 x 152 (mm)
ISBN-13: 9780128201671