Active Site-directed Enzyme Inhibitors: Design Concepts

Enzyme-catalyzed reactions are essential for life processes, but their inappropriate up-regulation can lead to diseases. Enzyme inhibitors are a major class of therapeutic agents, and this handbook provides concepts for designing effective inhibitors for various enzymatic reactions. It is organized by different concepts and applications, making it an ideal resource for researchers and students in medicinal chemistry.

Format: Hardback
Length: 200 pages
Publication date: 13 September 2023
Publisher: Royal Society of Chemistry

Enzyme-catalyzed reactions, or enzymatic reactions, play a vital role in our biological system, facilitating a wide range of life processes, including gene transcription and metabolism. However, the inappropriate upregulation of these enzymatic reactions is a significant contributor to human diseases such as cancer and metabolic disorders. As a result, enzyme inhibitors, which specifically target these enzymatic reactions, have become a major class of therapeutic agents on the global drug market.

One crucial question arises: how can we efficiently design enzyme inhibitors? To address this, this handbook stands as a groundbreaking resource, presenting the concepts that have proven successful in generating effective active site-directed inhibitors for various enzymatic reactions.

The book is organized in a logical and comprehensive manner, with each concept being delineated in detail. For each concept, there is a clear explanation of its mode of operation and its applications across different types of enzymatic reactions. By leveraging the knowledge and insights provided in this handbook, researchers and students alike can swiftly and efficiently obtain effective active site-directed inhibitors for any enzymatic reaction under study, bypassing the need for time-consuming library screening and biostructure-based techniques.

This handbook serves as an invaluable resource for researchers seeking to consult or supplement their studies in medicinal chemistry and related courses. Its comprehensive coverage and user-friendly approach make it an essential tool for anyone interested in advancing the field of enzyme inhibition and its potential applications in medicine.

Weight: 446g
Dimension: 234 x 156 (mm)
ISBN-13: 9781839161971