Amino Acids: Insights and Roles in Heterocyclic Chemistry: Volume 3: N-Carboxyanhydrides, N-Thiocarboxyanhydrides, Sydnones, and Sydnonimines

Volume 3: N-Carboxyanhydrides, N-Thiocarboxyanhydrides, and Sydnones of a four-volume book set provides up-to-date information on alpha-amino acids, protecting groups, and heterocyclic compounds. It covers NCA/NTA monomers, ring-opening polymerization, and mass spectrometric techniques. The other volumes in the set cover protecting groups, hydantoins, thiohydantoins, 2,5-diketopiperazines, azlactones, and oxazolidin-5-ones. The set is valuable for graduate students, senior students, professors, and researchers in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, and proteins and peptides.

Format: Hardback
Length: 364 pages
Publication date: 26 May 2023
Publisher: Apple Academic Press Inc.

This is the third volume of a groundbreaking four-volume book set that offers readers comprehensive and up-to-date knowledge on α-amino acids. This comprehensive resource covers various aspects, including the potential challenges in working with α-amino acids, the protective groups used for the carboxyl, amino, and side chain groups of amino acids, and the most popular heterocyclic compounds derived from α-amino acids.

Within this extensive compilation, readers will find a wealth of information on hydantoins, thiohydantoins (including 2-thiohydantoins, 4-thiohydantoins, 2,4-dithiohydantoins), 2,5-diketopiperazines, N-carboxyanhydrides, N-thiocarboxyanhydrides, sydnones, sydnonimines, azlactones, pseudoazlactones, and oxazolidin-5-ones. This volume stands as the first resource to gather all the heterocycles that can be directly synthesized from α-amino acids. Moreover, it provides detailed mechanistic discussions and experimental procedures for almost all types of synthetic methods employed for these heterocycles.

Volume 3: N-Carboxyanhydrides, N-Thiocarboxyanhydrides, and Sydnones delves into the realm of two distinct types of heterocyclic compounds that originate from alpha-amino acids: N-carboxyanhydrides (NCAs) and N-thiocarboxyanhydrides (NTAs). The volume offers detailed insights into the synthesis, characterization, and practical applications of these compounds. It also provides a comprehensive overview of over 10 initiating systems used for the ring-opening polymerization of NCA monomers, which is crucial for the production of living polypeptides/polypeptoids.

Furthermore, the volume includes methods to characterize these prepared polypeptides/polypeptoids, with a particular focus on two modern mass spectrometric techniques: MALDI-TOF and ESI-TOF. These techniques are explained in detail with practical examples and theoretical foundations, showcasing their utility in elucidating molecular weights of proteins based on ESI-TOF spectra. This unique feature adds depth and practicality to the resource, making it invaluable for researchers and practitioners in the field.

In summary, this third volume of the four-volume book set is a vital resource for anyone seeking comprehensive knowledge on α-amino acids, their derivatives, and their applications in various fields. It provides a wealth of information, detailed discussions, and practical insights, making it an essential tool for researchers, students, and professionals in the field of chemistry and biochemistry.

Weight: 860g
Dimension: 234 x 156 (mm)
ISBN-13: 9781774911563