AMYOTROPHIC LATERAL SCLEROSIS

Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions, a book by Dr. Christopher A. Shaw and Jessica R. Morrice, provides a practical and powerful perspective on ALS as a heterogeneous spectrum of disorders. It discusses pathologic features common to all cases, genetic and environmental etiologies, and animal models. It is an indispensable resource for clinical neurologists, healthcare providers, caretakers, clinicians, and researchers studying motor neuron disease.

Format: Hardback
Length: 192 pages
Publication date: 25 March 2021
Publisher: WILEY

Discover state-of-the-art research findings on ALS from leading authors and editors in the field.

In "Spectrums of Amyotrophic Lateral Sclerosis: Heterogeneity, Pathogenesis & Therapeutic Directions," distinguished researchers and editors Dr. Christopher A. Shaw and Jessica R. Morrice deliver a practical and powerful perspective on Amyotrophic Lateral Sclerosis (ALS) as a heterogeneous spectrum of disorders. This increasingly accepted point-of-view allows researchers and medical professionals to develop better targeted interventions and more precise therapies.

In the book, readers will find chapters on a wide variety of critical issues facing ALS researchers and healthcare practitioners treating ALS sufferers, including animal models of ALS, neuronal support cells known to have a pivotal role in ALS, and current challenges in ALS clinical trials, among others. The authors describe pathologic features common to all cases of ALS and why animal models, though crucial, should be interpreted with caution. Finally, multiple genetic and environmental etiologies of the disease are discussed.

Readers will also benefit from the inclusion of:

A thorough introduction to ALS as a spectrum disease and the implications for models, therapeutic development, and clinical trial design.

Explorations of the genetic basis of ALS, prospective ALS etiologies, and the involvement of microbiome in ALS.

Discussions of ALS-PDC and environmental risk factors, protein aggregation in ALS, defects in RNA metabolism in ALS, and the non-cell autonomous nature of ALS and the involvement of glial cells.

Examinations of animal models of ALS and perspectives on previously failed ALS therapeutics and current therapeutic strategies.

Perfect for clinical neurology.

Weight: 622g
Dimension: 175 x 251 x 19 (mm)
ISBN-13: 9781119745495