Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive book on anti-aging strategies, providing foundational knowledge on the mechanisms of aging and current approaches. Aging research has revealed that genetics and environmental factors determine the rate of aging, with hallmarks of aging describing molecular and cellular processes.

Format: Paperback / softback
Length: 410 pages
Publication date: 01 May 2022
Publisher: Elsevier Science & Technology

Anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals.

The first hallmark of aging is cellular senescence, which is the gradual loss of the ability of cells to divide and renew themselves. This is caused by a variety of factors, including DNA damage, oxidative stress, and inflammation. Cellular senescence can lead to a variety of age-related diseases, including cancer, diabetes, and heart disease.

Another hallmark of aging is mitochondrial dysfunction, which is the decline in the function of mitochondria, the powerhouses of cells. Mitochondria produce energy for cells, and they also play a role in regulating cellular metabolism and apoptosis (cell death). Mitochondrial dysfunction can lead to a variety of age-related diseases, including Parkinson's disease, Alzheimer's disease, and heart disease.

A third hallmark of aging is inflammation, which is the body's response to injury or infection. Chronic inflammation can lead to a variety of age-related diseases, including cancer, diabetes, and heart disease. Inflammation can also contribute to the development of atherosclerosis, which is the buildup of plaque in the arteries.

Finally, the fourth hallmark of aging is oxidative stress, which is the damage to cells caused by free radicals. Free radicals are produced by a variety of factors, including ultraviolet radiation, smoking, and pollution. Oxidative stress can lead to a variety of age-related diseases, including cancer, diabetes, and heart disease.

There are a variety of anti-aging strategies and approaches that have been developed to address these hallmarks of aging. These include lifestyle changes, such as diet and exercise, as well as pharmacological interventions, such as anti-inflammatory drugs and antioxidants. Lifestyle changes, such as diet and exercise, are important for maintaining good health and reducing the risk of age-related diseases. A healthy diet rich in fruits, vegetables, whole grains, and lean protein can help reduce the risk of cancer, diabetes, and heart disease. Regular exercise can help improve cardiovascular health, reduce inflammation, and improve cognitive function.

Pharmacological interventions, such as anti-inflammatory drugs and antioxidants, can also help address the hallmarks of aging. Anti-inflammatory drugs, such as ibuprofen and naproxen, can help reduce inflammation and improve cardiovascular health. Antioxidants, such as vitamin C and vitamin E, can help protect cells from damage caused by free radicals.

In addition to these strategies, there is also ongoing research into the development of new anti-aging drugs and therapies. One area of research is the use of stem cells to repair damaged tissue and slow the aging process. Stem cells can be used to replace damaged heart tissue, for example, or to repair damaged brain tissue in patients with Alzheimer's disease.

Another area of research is the use of gene therapy to modify the genes that contribute to aging. Gene therapy can be used to correct genetic defects that cause age-related diseases, or to modify genes that promote longevity.

Finally, there is also ongoing research into the use of nanotechnology to develop new anti-aging therapies. Nanotechnology can be used to deliver drugs and other therapies directly to cells, making them more effective and reducing the risk of side health complications.

In conclusion, anti-Aging Drug Discovery on the Basis of Hallmarks of Aging is a comprehensive and timely book on all aspects of anti-aging strategies. The book provides comprehensive, foundational knowledge on the mechanisms of aging and current anti-aging strategies and approaches developed. Aging research has experienced an unprecedented advance over recent years with the discovery that the rate of aging is determined, at least to some extent, mainly by our genetics and modulated by environmental factors. The hallmarks of aging describe the molecular and cellular processes that govern biological aging and their variation in individuals. There are a variety of anti-aging strategies and approaches that have been developed to address these hallmarks of aging, including lifestyle changes, such as diet and exercise, as well as pharmacological interventions, such as anti-inflammatory drugs and antioxidants. In addition to these strategies, there is also ongoing research into the development of new anti-aging drugs and therapies, such as stem cells, gene therapy, and nanotechnology. By understanding the hallmarks of aging and developing effective strategies to address them, we can improve our health and quality of life as we age.

Dimension: 235 x 191 (mm)
ISBN-13: 9780323902359