Antimicrobial Resistance: Underlying Mechanisms and Therapeutic Approaches

Antimicrobial resistance (AMR) is a global public health threat that requires immediate attention and action from the scientific community. This book compiles and presents the latest aspects of AMR, including its biology, persistence, and spread, and novel approaches to combating it. It emphasizes current developments in natural products, nanomaterials, and CRISPR-Cas-based antimicrobials, and is intended for students, researchers, public health professionals, and industry experts.

Format: Paperback / softback
Length: 605 pages
Publication date: 05 January 2023
Publisher: Springer Verlag, Singapore

Antimicrobial resistance (AMR) poses a significant global public health threat that demands immediate attention and concerted action from the scientific community. This comprehensive book aims to compile and present the latest and most essential aspects of AMR, encompassing its biology, persistence, and spread, as well as innovative approaches to combat this formidable challenge.

The book begins by delving into the mechanisms and pathways of AMR, shedding light on the factors that contribute to its emergence and dissemination. It then explores a range of strategies and approaches for combating AMR, including microbial pathogenesis, the identification of AMR traits and major mechanisms underlying drug resistance, and the emerging technologies and techniques for combating AMR.

A particular emphasis is placed on current developments in natural products, such as potent phyto-molecules, antimicrobial peptides, and endophytes, which have shown promising efficacy against drug-resistant microbes. These natural compounds target key drug-resistance determinants, including efflux pumps, biofilms, quorum sensing, and plasmids, in these bacterial pathogens.

Furthermore, the book explores the applications of nanomaterials in tackling AMR and the emerging field of CRISPR-Cas-based precise sequence-specific antimicrobials. These cutting-edge technologies offer promising solutions for addressing AMR, particularly in the context of drug-resistant bacteria.

Designed with students and researchers in basic and medical microbiology, biotechnology, and public health in mind, this informative book provides a comprehensive overview of AMR and its implications. It is also valuable to industry experts and professionals involved in AMR research and drug-designing efforts. By fostering knowledge and understanding of AMR, this book contributes to the development of effective strategies and interventions to combat this global health threat.

Weight: 937g
Dimension: 235 x 155 (mm)
ISBN-13: 9789811631221
Edition number: 1st ed. 2022