Cancer Metastasis Through the Lymphovascular System

This textbook provides an in-depth explanation of the process of cancer metastasis,from the initial cell in the primary site to distant sites. It highlights the latest knowledge on molecular biology, diagnosis, and treatment, with a focus on the role of the immune system and the sentinel lymph node. It also discusses imaging techniques and systemic therapy and previews emerging topics in cancer metastasis research.

Format: Hardback
Length: 806 pages
Publication date: 26 June 2022
Publisher: Springer Nature Switzerland AG

This comprehensive textbook delves into the intricate process of cancer metastasis, spanning from a single cell in the primary site to its arduous journey to the sentinel lymph node, serving as the primary gateway, and eventually reaching distant sites. A distinguished panel of experts highlights the most recent knowledge on critical topics in molecular biology, diagnosis, and treatment of metastatic cancer.

The book begins with a comprehensive overview of the genetic and molecular mechanisms that drive or hinder cancer metastasis, either through lymphatic pathways to lymph nodes or through vascular routes to distant sites. This foundational knowledge sets the stage for subsequent chapters.

The book then delves into the intricate interplay between the immune system within the primary tumor and the lymph node, emphasizing the significance of the microenvironment at the metastatic site. Special attention is given to the role of the sentinel lymph node in cancer metastasis, highlighting its diagnostic and therapeutic implications.

State-of-the-art imaging techniques for early detection of cancer and cancer metastases are extensively discussed, including magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET). Liquid biopsies, which involve the analysis of bodily fluids for cancer biomarkers, are also explored in the context of sarcoma, prostate, gastrointestinal, and lung cancer.

Clinical patterns of malignant tumors arising in different organ systems are compared, described, and analyzed to identify similarities and/or differences. This comparative analysis aims to shed light on the underlying mechanisms driving cancer metastasis and inform personalized cancer therapy strategies.

The book concludes with a detailed discussion of surgical intervention, radiation therapy, and systemic therapy for primary and metastatic cancer. It also provides a brief preview of emerging topics in cancer metastasis research, such as personalized cancer therapy, cancer stem cells, unique molecular mechanisms of virus-induced cancer, the impact of the microbiome on cancer metastasis, and the application of artificial intelligence in cancer metastasis research.

By offering a comprehensive and up-to-date understanding of cancer metastasis, this textbook serves as a valuable resource for researchers, clinicians, and healthcare professionals alike. It empowers individuals with the knowledge necessary to combat this complex disease and improve patient outcomes.

Weight: 2474g
Dimension: 279 x 210 (mm)
ISBN-13: 9783030930837
Edition number: 1st ed. 2022