Cell Therapy Against Cerebral Stroke: Comprehensive Reviews for Translational Researches and Clinical Trials

Cell therapy for stroke is a promising treatment option with limited regenerative capacity. Experts review optimal cell sources and ongoing clinical trials in Japan.

\n Format: Paperback / softback
\n Length: 156 pages
\n Publication date: 13 July 2018
\n Publisher: Springer Verlag, Japan
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Cerebral stroke remains a formidable cause of mortality and disability, despite extensive research efforts. Despite the limited regenerative capacity of injured neural tissue in the central nervous system (CNS), the therapeutic potential of cell transplantation has been explored for various pathological conditions, including traumatic brain injury, traumatic spinal cord injury, degenerative diseases, demyelinating diseases, and ischemic stroke.

In recent years, a substantial body of evidence has emerged, indicating that cell transplantation holds immense promise as a therapeutic approach for stroke. The authors, renowned experts in neurosurgery, provide comprehensive reviews on optimal cell sources and address various challenges associated with translational research. Furthermore, they outline ongoing clinical trials in Japan, highlighting the progress being made in this field.

The book is divided into two parts. The first part focuses on translational research, delving into the preclinical studies and animal models that have paved the way for clinical trials. The authors discuss the various cell types used in transplantation, including stem cells, progenitor cells, and mesenchymal stem cells, and their potential benefits in repairing damaged brain tissue. They also explore the mechanisms of cell migration, differentiation, and integration into the CNS, as well as the strategies employed to enhance the survival and function of transplanted cells.

The second part of the book focuses on clinical trials, providing detailed descriptions of ongoing studies in Japan. The authors outline the design and methodology of these trials, including patient selection criteria, treatment protocols, and outcomes assessment. They discuss the results of previous studies and provide insights into the potential benefits and limitations of cell transplantation as a stroke therapy.

Overall, this book serves as a valuable resource for researchers, clinicians, and healthcare professionals interested in cell therapy for stroke. It provides a comprehensive overview of the current state of knowledge in this field, highlighting the potential benefits and challenges associated with cell transplantation as a treatment option. The authors' expertise and insights make this book an essential read for those seeking to advance the field of stroke therapy.

\n Weight: 91g\n
Dimension: 229 x 152 x 5 (mm)\n
ISBN-13: 9784431567660\n
Edition number: Softcover reprint of the original 1st ed. 2017\n