Concepts and Models for Drug Permeability Studies: Cell and Tissue based In Vitro Culture Models

Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting drug permeability, covering immortalized cells, primary cells, and tissue-based models. It discusses the equivalence between in vitro and in vivo conditions and highlights how each model may provisionally resemble different drug absorption routes. Updated chapters and new chapters reflect emerging directions and trends in drug permeability models.

Format: Hardback
Length: 500 pages
Publication date: 01 February 2024
Publisher: Elsevier - Health Sciences Division

Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, provides a comprehensive overview of the most important developments in in vitro models for predicting drug permeability. The book is structured around three different approaches: immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, primary cells isolated from living organisms and directly cultured as barrier monolayers, and tissue-based models constructed with cell lines and extracellular matrix that resemble the tridimensional structure of mucosae and other biological membranes, or animal/patient-derived tissues. Each model is covered in detail, including the protocol of generation and application for specific drugs/drug delivery systems. The equivalence between in vitro cell and tissue models and in vivo conditions is discussed, highlighting how each model may provisionally resemble different drug absorption routes. Chapters included in the first edition were updated with relevant data published in recent years, while four new chapters were included to reflect new emerging directions and trends in drug permeability models. Researchers studying mucosal biology can use this book to familiarize themselves and exploit the synergic effect of mucosal delivery systems and biomolecules.

Dimension: 229 x 152 (mm)
ISBN-13: 9780443155109
Edition number: 2 ed