Diabetes and Kidney Disease

This book is a comprehensive resource on diabetic kidney disease, covering recent research, pathophysiology, clinical features, and treatment modalities. It is convenient for physicians and students interested in reducing the burden of diabetes and diabetic kidney disease.

Format: Paperback / softback
Length: 679 pages
Publication date: 22 December 2022
Publisher: Springer Nature Switzerland AG

This book is a valuable resource for anyone interested in diabetic kidney disease. It provides a comprehensive yet concise overview of the latest research, pathophysiology, structural alterations, and clinical features of the condition. The book summarizes recent evidence-based clinical treatment modalities for preventing and managing diabetic kidney disease, covering general clinical aspects and novel approaches being developed by leading researchers in the field. It is a convenient compendium for physicians involved in the care of diabetic patients with varying degrees of kidney involvement, and it is also a valuable resource for medical residents and students interested in the current status and future approaches to reducing the burden of diabetes and diabetic kidney disease.

Diabetic nephropathy, a significant complication of diabetes, is a major cause of kidney failure and premature death worldwide. The pathophysiology of diabetic nephropathy is complex and multifactorial, involving changes in the glomerulus, tubules, and vasculature. The glomerulus is the primary filtering unit of the kidney, and damage to this structure leads to the accumulation of waste products and fluid in the urine. Tubular damage can result in impaired urine filtration, electrolyte imbalances, and the generation of toxic waste products. Vasculopathy, which refers to damage to the blood vessels in the kidney, can lead to reduced blood flow and oxygenation, which can further exacerbate kidney damage.

In addition to these structural alterations, diabetic nephropathy is characterized by clinical features such as proteinuria, hypertension, and hyperlipidemia. Proteinuria is the presence of excess protein in the urine, which can be a sign of kidney damage. Hypertension is a common complication of diabetes, and it can contribute to the progression of kidney disease by increasing the workload on the kidneys. Hyperlipidemia is a condition in which there is an excess of lipids in the blood, which can also contribute to the development of kidney disease by promoting inflammation and atherosclerosis.

The treatment of diabetic nephropathy involves a combination of lifestyle modifications, medication, and, in some cases, dialysis or kidney transplantation. Lifestyle modifications include controlling blood sugar levels, maintaining a healthy diet, and exercising regularly. Medication such as angiotensin-converting enzyme inhibitors (ACE inhibitors) and angiotensin receptor blockers (ARBs) can help control blood pressure and reduce proteinuria. In some cases, dialysis or kidney transplantation may be necessary to remove excess waste products and fluid from the body.

Despite advances in treatment, diabetic nephropathy remains a significant challenge for healthcare providers. The prevalence of the condition is increasing, particularly in developing countries, and there is a need for more effective prevention strategies and treatments. Research in the field is ongoing, and new treatments and therapies are being developed to improve the outcomes of patients with diabetic nephropathy.

In conclusion, diabetic nephropathy is a complex and multifactorial condition that affects millions of people worldwide. It is characterized by structural alterations in the glomerulus, tubules, and vasculature, as well as clinical features such as proteinuria, hypertension, and hyperlipidemia. Treatment involves a combination of lifestyle modifications, medication, and, in some cases, dialysis or kidney transplantation. While progress has been made in treatment, there is still a need for more effective prevention strategies and treatments to improve the outcomes of patients with diabetic nephropathy.

Weight: 1050g
Dimension: 235 x 155 (mm)
ISBN-13: 9783030860226
Edition number: 2nd ed. 2022