Drug Metabolism Handbook: Concepts and Applications in Cancer Research

Drug Metabolism Handbook: Concepts and Applications in Cancer Research, Second Edition is a comprehensive guide to drug metabolism concepts and applications in drug development and cancer treatment. It covers metabolism basics, techniques, and technologies, as well as drug interactions, toxicity, and allergic reactions. The book is ideal for medicinal chemists, pharmaceutical scientists, and toxicologists, and will also be valuable for analytical chemists and drug discovery professionals.

Format: Hardback
Length: 1056 pages
Publication date: 09 March 2023
Publisher: John Wiley & Sons Inc

In the extensively revised second edition of Drug Metabolism Handbook: Concepts and Applications in Cancer Research, a distinguished team of researchers presents an in-depth and comprehensive exploration of the drug metabolism system, accompanied by detailed illustrations and explanations of the latest tools and techniques employed in research, pharmacology, and medicine. The book delves into various crucial concepts, such as the creation of new molecular entities, drug development, troubleshooting, and other highly relevant topics, guiding readers through novel applications in pharmaceutical research, development, and assessment.

The latest edition of this handbook offers updated content on metabolism basics and the application of a diverse range of new techniques to cancer treatment, including mass spectrometry, imaging, metabolomics, and immunotherapy. It also provides in-depth case studies highlighting the role of metabolism in drug development.

Furthermore, readers will benefit from:

A thorough introduction to drug metabolism, encompassing a historical perspective, factors influencing metabolism, and biotransformations in drug metabolism.
Comprehensive discussions of technologies for in vitro and in vivo studies, including mass spectrometry and accelerating metabolite identification with mass spectrometry.
In-depth explorations of drug interactions, including discussions of enzyme inhibition and the characterization of cytochrome P450 mechanism-based inhibition.
Fulsome treatments of drug toxicity, including the role of drug metabolism in toxicity and allergic reactions to drugs.

This handbook is an invaluable resource for medicinal chemists, pharmaceutical scientists, and toxicologists, providing a comprehensive and up-to-date understanding of drug metabolism concepts and their applications in cancer research and beyond.

ISBN-13: 9781119851011
Edition number: 2 ed