Essentials of Pharmatoxicology in Drug Research, Volume 1: Toxicity and Toxicodynamics

Toxicity and Toxicodynamics,Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an overview on toxicology,risk assessment,mechanisms,and omics and computer-aided technologies for predictive toxicology. It also covers state-of-art testing,dose selection,and clinical interventions for acute poisoning.

Format: Paperback / softback
Length: 752 pages
Publication date: 22 March 2023
Publisher: Elsevier Science Publishing Co Inc

Toxicity and Toxicodynamics,Volume One in the Essentials of Pharmatoxicology in Drug Research series provides an in-depth overview of the fundamentals of toxicology, risk assessment, and mechanisms. The book delves into various topics, including the diverse cellular responses to chemical toxicants, the underlying mechanisms of drug toxicity, and their significance in pharmaceutical product development. It explores the use of omics and computer-aided technologies in mechanistic and predictive toxicology, covering state-of-the-art testing methodologies for assessing detrimental pathways, determining appropriate doses in toxicity studies, and examining the role of regulatory agencies in these endeavors. Additionally, the book discusses clinical interventions, such as pharmacotherapy and managed care strategies, for managing acute poisoning. This comprehensive volume serves as a valuable resource for individuals seeking to gain a deeper understanding of the drug development process in toxicology and for those seeking to stay updated on the latest concepts in this field.

Toxicology, a multidisciplinary field encompassing various scientific disciplines, plays a crucial role in drug research and development. Toxicity and Toxicodynamics,Volume One in the Essentials of Pharmatoxicology in Drug Research series, authored by renowned experts in the field, offers a comprehensive and insightful exploration of the essentials of toxicology, risk assessment, and mechanisms.

The book begins by providing a foundational understanding of toxicology, encompassing the principles, concepts, and methodologies employed in the study of chemical toxicants and their effects on living organisms. It delves into the various types of cellular responses to toxicants, including oxidative stress, inflammation, and apoptosis, and explores the mechanisms by which these responses contribute to toxicological outcomes.

Drug toxicity, a significant concern in drug development, is extensively discussed in the book. It explores the mechanisms by which drugs exert their toxic effects, including pharmacodynamic and pharmacokinetic interactions, as well as drug-drug interactions. The relevance of drug toxicity to pharmaceutical product development is emphasized, highlighting the importance of conducting thorough toxicological assessments to ensure the safety and efficacy of drug candidates.

The book also examines omics and computer-aided technologies for mechanistic and predictive toxicology. It discusses the use of high-throughput screening methods, such as genomics, proteomics, and metabolomics, to identify potential toxicants and predict toxicological outcomes. These technologies have revolutionized toxicological research by providing a more efficient and cost-effective approach to identifying and characterizing toxicants.

State-of-art testing in the evaluation of detrimental pathways, dose selection in toxicity studies, and the role of regulatory agencies in toxicity studies are covered in detail. The book provides insights into the regulatory frameworks and guidelines that govern drug development, emphasizing the importance of compliance and adherence to these regulations.

In addition to toxicological assessments, the book discusses clinical interventions, such as pharmacotherapy and managed care strategies, for managing acute poisoning. It explores the use of antidotes, supportive care, and other therapeutic interventions to mitigate the harmful effects of toxicants and improve patient outcomes.

Toxicity and Toxicodynamics,Volume One in the Essentials of Pharmatoxicology in Drug Research series is a valuable resource for individuals learning more about the drug development process related to toxicology. It serves as a comprehensive guide to the fundamentals of toxicology, risk assessment, and mechanisms, providing insights into the latest advancements and developments in the field. The book is particularly useful for researchers, scientists, pharmacists, and medical professionals involved in drug research, development, and clinical practice.

In conclusion, Toxicity and Toxicodynamics,Volume One in the Essentials of Pharmatoxicology in Drug Research series is a must-read for anyone interested in drug research and development. It offers a comprehensive and insightful exploration of the essentials of toxicology, risk assessment, and mechanisms, providing valuable insights into the drug development process and the safety of pharmaceutical products. The book is a valuable resource for researchers, scientists, pharmacists, and medical professionals involved in drug research, development, and clinical practice.

Weight: 1532g
Dimension: 192 x 235 x 40 (mm)
ISBN-13: 9780443158407