Ferroptosis in Health and Disease

Ferroptosis is an iron-dependent form of non-apoptotic cell death, and this updated and expanded volume provides new insights on its regulation at multiple levels, including epigenetic, transcriptional, posttranscriptional, and posttranslational layers. It covers the two major pathways through which ferroptosis can occur and describes the multiple regulators and transcription factors involved, such as GPX4, ACSL4, and NFE2L2. The contributions also explore how dysregulated ferroptosis is involved in human diseases.

Format: Hardback
Length: 490 pages
Publication date: 29 October 2023
Publisher: Springer International Publishing AG

Ferroptosis, an iron-dependent form of non-apoptotic cell death, is explored in this updated and expanded volume, shedding new light on its mechanisms. The book delves into the two primary pathways of ferroptosis: the extrinsic or transporter-dependent pathway and the intrinsic or enzyme-regulated pathway. Readers will gain insights into the multiple levels of regulation involved in this unique cell death process. The contributions cover epigenetic, transcriptional, posttranscriptional, and posttranslational layers, highlighting key regulators and transcription factors such as GPX4, ACSL4, and NFE2L2. Additionally, the book provides a comprehensive overview of the integrated molecular machinery of ferroptosis and its involvement in human diseases.

Weight: 910g
Dimension: 235 x 155 (mm)
ISBN-13: 9783031391705
Edition number: 2nd ed. 2023